In Vivo Toxicity Evaluation of PEGylated CuInS2/ZnS Quantum Dots in BALB/c Mice

Conclusion In this study, the long-term toxicity of CuInS2/ZnS QDs in male mice at a high dose of 25 mg/kg and low dose of 2.5 mg/kg was investigated. Following injection, the CuInS2/ZnS QDs accumulated in the liver and spleen over 90 days. There were no obvious changes in body weight or behavior. Routine blood tests and biochemical examination showed that most of the measured parameters were not significantly different between the QDs-treated group and the control group. H&E staining demonstrated that there were no distinct histopathological abnormalities related to treatment with the CuInS2/ZnS QDs. In view of these results, we suggest that CuInS2/ZnS QDs have high biocompatibility in vivo and can be utilized as optical probes or nanocarriers for selected in vivo biological applications. Ethics Statement This study was carried out in accordance with the recommendations of ‘the Care and Use of Laboratory Animals Center of Shenzhen University’. The protocol was approved by the ‘Experimental Animal Ethics Committee of Shenzhen University’ (Permit No. 201512022). Author Contributions GL and WZ conceptualized and designed the manuscript. XW and GL supported for administrative. WZ, LL, YC, and DL experimented and collected the data. WZ, ZY, and JW analyzed the data and drafted the manuscript. TC critically revised the manuscript. Funding The authors would like to acknowledge the funding support from National Natural Science Foundation of ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research