Biogenesis and Function of Circular RNAs in Health and in Disease
Conclusion The elucidation of the function of circRNAs is an emerging field of science with a tremendous potential after previously being dismissed as RNA artifacts. They are ubiquitously expressed and thousands of members have already been identified. This fact only expands their potential to possibly enhance our knowledge to understand the difference between health and disease. Owing to their structure stability and their presence in exosomes circRNAs may also exert their function in an autocrine, paracrine and possible endocrine fashion. In addition, the fact that circRNAs are widely distributed in the cellular compartment as well as in the extracellular space in various body fluids affords them to become ideal candidates as reliable biomarkers for various human diseases. As in any emerging field caution is advised in interpreting new findings. To date studies are merely descriptive in nature. More in depth analysis about the function and regulation of identified circRNAs is needed to understand their mechanism of action. These RNA molecules hold great promise as biomarkers of disease because of their high resistance to exonuclease activity and might even be more highly expressed than their linear counterparts. Especially their putative role as miRNA sponges makes them interesting targets for future investigations. In the future circRNA-based therapies might be introduced. The concept of establishing circRNAs as therapeutics in the future relies on the stability and expre...
Vaccines protecting against influenza, hepatitis B and rabies are less effective for obese people. As scientists develop a Covid-19 vaccine, experts say obesity could be an impediment, a sobering prospect for the US, where nearly half of all adults are obese.
SUPPLEMENTS could be used to improve the health of your heart, as well as to protect against high blood pressure symptoms and signs. Add these cheap garlic capsules to your diet to lower your risk of heart problems, including heart attacks and heart disease.
Advice and information on how to look after your mental health and wellbeing during the coronavirus (COVID-19) outbreak. Update in this version (published 4th August 2020) - added translated documents in Arabic, Bengali, Chinese CN, Chinese HK, French, Gujarati, Polish, Portuguese, Punjabi and Urdu.
This is advice for parents and carers on looking after the mental health and wellbeing of children or young people during the coronavirus (COVID-19) outbreak. Update in this version (published 4th August 2020) - added translated documents in: Arabic, Bengali, Chinese CN, Chinese HK, French, Gujarati, Polish, Portuguese, Punjabi and Urdu.
Those suffering from cancer, heart conditions, strokes, diabetes and lung disease are among the worst affected by delays to their diagnosis and care, a survey of senior doctors reveals.
How does sustained virologic response from direct-acting antiviral and interferon-based treatments impact the risk of developing hepatocellular carcinoma?Journal of Viral Hepatitis
University of Leeds experts found heart attack admissions dropped by 40 per cent in April and May in England. They say it may have been an 'unintended consequence' of Stay At Home' slogan.
DIABETES type 2 symptoms may include feeling unusually tired, passing more urine than normal, and having cuts or wounds that take longer to heal than expected. But, you could also be at risk of high blood sugar if you notice a change to the appearance of your stools. What does your poo look like?
HIGH blood pressure is a largely symptomless silent killer. If a person ignores their blood pressure because they think a certain symptom will alert them to the problem, they are taking a dangerous chance with their life. There are two waring signs which lay in a person's face.
The objective of this study was to report the incidence of alopecia arising in patients treated with vismodegib, assessing its characteristics, grade of severity, and time of onset.Skin Appendage Disord
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