Long-Term Outcomes of Three-Dimensional High-Dose-Rate Brachytherapy for Locally Recurrent Early T-Stage Nasopharyngeal Carcinoma

Conclusions: 3D-HDR-BT achieves favorable clinical outcomes with mild late toxicity in patients with locally rNPC. Introduction Nasopharyngeal carcinoma (NPC), a tumor of epithelial origin, is a malignant disease of the head and neck common in southern China, especially in Guangdong province (1). As a result of advances in modern imaging and irradiation techniques, the 5-year overall survival (OS) of patients with newly diagnosed NPC without metastasis has reached 75% after external beam radiotherapy (EBRT) in Asia (2, 3). However, local recurrence, which occurs in 18–40% of patients, remains a major reason for treatment failure (4, 5). Thus, treatment of patients with recurrent NPC (rNPC) is a major challenge for clinicians. Current therapies for locally rNPC include surgery, stereotactic radiosurgery, conventional radiotherapy, intensity-modulated radiation therapy (IMRT), and brachytherapy (BT) (6). Patients with rNPC should usually be considered for reirradiation, which can be performed by intracavitary brachytherapy (ICBT) with or without EBRT. BT offers the possibility of high-dose irradiation with a rapid dose fall-off beyond the target volume, thereby sparing surrounding critical structures (7). Numerous studies have demonstrated the categorical benefit of BT in achieving favorable long-term local control and improving the survival outcome of patients with rNPC (8, 9). Computed tomography (CT)-guided high-dose-rate brachytherapy (HDR-BT) is an afterloadin...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

Related Links:

Authors: Li N, Huang YH Abstract A patient with central venous occlusion at the junction of the superior vena cava and right atrium underwent endovascular revascularization. The leakage of contrast agents was detected during sharp recanalization that was then managed with covered stent deployment. The initial symptom of facial swelling disappeared and the vital signs were stable after treatment. Regrettably, the patient suffered from the clinical features of cardiac tamponade on the third day post-treatment, which was confirmed by computed tomography. Finally, a pericardial effusion was drained, leading to dramatic...
Source: The Journal of Vascular Access - Category: Surgery Tags: J Vasc Access Source Type: research
Publication date: Available online 2 July 2020Source: Artificial Intelligence in MedicineAuthor(s): Jacques Bouaud, Sylvia Pelayo, Jean-Baptiste Lamy, Coralie Prebet, Charlotte Ngo, Luis Teixeira, Gilles Guézennec, Brigitte Seroussi
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
Publication date: Available online 3 July 2020Source: MethodsAuthor(s): Xin Chen, China Xien Liu, China Ji Wu
Source: Methods - Category: Molecular Biology Source Type: research
Conclusions: Operative laparoscopy under conscious sedation and local anesthesia appears to be a feasible technique in gynecologic surgery with no adverse patient outcomes. PMID: 32612345 [PubMed - in process]
Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - Category: Surgery Tags: JSLS Source Type: research
CONCLUSION: it became evident that palliative care in primary health care has been gradually developed, but it is necessary to consider the organization of primary health care and the social policies that support or weaken it, being considered a complex challenge. PMID: 32609270 [PubMed - in process]
Source: Revista Latino-Americana de Enfermagem - Category: Nursing Authors: Tags: Rev Lat Am Enfermagem Source Type: research
Publication date: Available online 2 July 2020Source: Redox BiologyAuthor(s): Mengling Li, Chengai Wu, Jibran Sualeh Muhammad, Dan Yan, Koichi Tsuneyama, Hideki Hatta, Zheng-Guo Cui, Hidekuni Inadera
Source: Redox Biology - Category: Biology Source Type: research
Publication date: Available online 26 June 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Sumanta Kar, Dinesh R. Katti, Kalpana S. Katti
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: 15 October 2020Source: Sensors and Actuators B: Chemical, Volume 321Author(s): Ayushi Agarwal, Krishnan Venkatakrishna, Bo Tan
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: Available online 2 July 2020Source: Chinese Chemical LettersAuthor(s): Bing Li, Huan Pang, Huaiguo Xue
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: Available online 1 July 2020Source: Chinese Chemical LettersAuthor(s): Keqing Huang, Guiting Liu, Zhipeng Gu, Jun Wu
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
More News: Academia | Anesthesia | Anesthesiology | Brachytherapy | Brain | Breast Cancer | Breast Carcinoma | Breast Needle Aspiration | Cancer | Cancer & Oncology | Carcinoma | Cervical Cancer | Chemotherapy | China Health | Clinical Trials | CT Scan | Cytology | Epistaxis (Nosebleeds) | Epithelial Cancer | External Beam Therapy | Head and Neck Cancer | Headache | Hong Kong Health | Intensity-Modulated Radiation Therapy | Iodine | Laboratory Medicine | Lower Endoscopy | Medical Ethics | Migraine | MRI Scan | Nasopharyngeal Cancer | Netherlands Health | Neurology | Neurosurgery | Norway Health | Oral Cancer | PET Scan | Prostate Cancer | Radiation Therapy | Radiography | Rectal Cancers | Reproduction Medicine | Singapore Health | Statistics | Study | Toxicology | Xerostomia