Trends in Colorectal Cancer Surveillance: Current Strategies and Future Innovations-

AbstractPurpose of ReviewThis review article strives to reflect on the historic surveillance debate in colorectal cancer, outline current strategies, and guidelines, and discuss new techniques being explored in surveilling colorectal adenocarcinoma.Recent FindingsWithin the past decade, major governing bodies have proposed surveillance guidelines with the goal of earlier identification of cancer recurrence, thereby possibly reducing the morbidity and mortality of necessary interventions. With the innovation of tissue-specific tumor markers and fluorescence endoscopy, the approach to surveillance may be changing. The use of these new modalities allows clinicians to provide a more risk-adjusted basis for care, which is predicted to equate to higher quality care.SummaryThe current surveillance guidelines provide an evidence-based framework for physicians and surgeons to follow. However, the influence of these novel surveillance techniques in colorectal cancer is yet to be realized and they ultimately have the potential to revolutionize care.
Source: Current Colorectal Cancer Reports - Category: Cancer & Oncology Source Type: research

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Authors: Paulson B, Kim IH, Namgoong JM, Kim YG, Lee S, Moon Y, Shin DM, Choo MS, Kim JK Abstract Colorectal cancer (CRC) is one of the most frequently lethal forms of cancer. Intramucosal injection allows development of better mouse models of CRC, as orthotopic xenografts allow development of adenocarcinoma in the submucosa of the mouse colon wall. In this paper, a method of orthotopic injection is monitored longitudinally using cellular-resolution real-time in vivo fluorescence microendoscopy, following the injection of three different cell lines: 3T3-GFP to confirm immunosuppression and HCT116-RFP cells to model...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
ConclusionThe fusion fascia of Fredet is useful to achieve CME and D3-L in right colon cancers with reduced risk of intraoperative complications. This structure is particularly suitable for minimally invasive surgery; therefore, we encourage awareness of the fascia of Fredet by colorectal surgeons.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
ConclusionsA focused training intervention was associated with a strong trend toward increased ADRs among certified endoscopists. While the described training interventions definitely show promise, further efforts around continuing professional developments activities are needed to more consistently improve ADRS among certified endoscopists.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
Authors: Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA Abstract Small bowel adenocarcinoma (SBA) is a rare malignancy of the gastrointestinal tract that has increased in incidence across recent years. Often diagnosed at an...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Authors: Baek SH, Lee JH, Yoo DR, Kim HY, Jin M, Jang AR, Yang DH, Byeon JS Abstract Colon interposition is a surgical procedure used for maintenance of luminal conduit after esophagectomy. Although epithelial neoplasia, such as adenoma and adenocarcinoma, may develop in the interposed colon, there are only few case reports on the condition. Due to the rarity of this condition, there is no definite consensus on recommending screening endoscopy for the early detection of neoplasia in the interposed colons. Here, we report a case of intramucosal adenocarcinoma in an interposed colon. Initial endoscopic resection for ...
Source: Clinical Endoscopy - Category: Gastroenterology Tags: Clin Endosc Source Type: research
AbstractBackgroundFactors associated with interval colorectal cancer (CRC) development in the inflammatory bowel disease (IBD) population remain unclear.AimsAmong a cohort of patients with interval CRC, we aimed to evaluate IBD characteristics, colonoscopy quality indicators, and surveillance guideline adherence.MethodsWe performed a retrospective review of IBD- and non-IBD-associated interval CRCs diagnosed between January 2007 and December 2014 within a large US healthcare system. We evaluated risk factors for CRC among patients with IBD. We assessed adherence to surveillance guidelines according to the American Society ...
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
CONCLUSIONS: CELS is a feasible treatment for colonic neoplasia where endoscopic resection alone is not technically possible. In case of severe co-morbidity ruling out segmental resection in patients diagnosed with T1 or T2 colorectal cancer, CELS treatment may be considered. FUNDING: none. TRIAL REGISTRATION: This study was assessed by The National Committee on Health Research Ethics (SJ-593), which concluded that the study required no approval from the Committee. The study was approved by the Danish Data Protection Agency (REG-126-2017). . PMID: 31315798 [PubMed - in process]
Source: Danish Medical Journal - Category: General Medicine Tags: Dan Med J Source Type: research
Risk factors for post-colonoscopy colonic neoplasm have been reported to be the history of colonic neoplasm at the index colonoscopy and family history of colorectal cancer (CRC) in first degree relatives (1stDR). Advanced adenoma (adenoma more than 10mm or high-grade dysplasia (HGD) or villous adenoma) has been used as surrogate marker for risk evaluation of colorectal adenocarcinoma. The aim of this study was to determine risk factors for post-colonoscopy advanced adenoma (PCAA) to validate U.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Sunday abstract Source Type: research
Colorectal cancers have two development theories. One is “adenoma-adenocarcinoma sequence” theory. The other is considered to emerge directly from normal epithelium, not through the adenomatous stage. This theory is called “de novo” pathway. We aimed to investigate clinicopathological characteristics and long-term prognosis mainly on depressed-typ e colorectal carcinomas considered as “de novo” pathway.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Monday abstract Source Type: research
Colorectal cancers are generally recognized to develop from polyps. This “adenoma-adenocarcinoma sequence” theory has been in the mainstream of development of colorectal neoplasms. However, another theory was revealed, which is considered to emerge directly from normal epithelium, not through the adenomatous stage. This theory is called “de novo” pathway. It has become possible to presume the histology of colorectal lesions using magnifying endoscopy (×100 folds, pit pattern classification) and endocytoscopy (×520 folds, EC classification).
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Tuesday abstract Source Type: research
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