A Review in Research Progress Concerning m6A Methylation and Immunoregulation

Conclusion and Perspectives Being exquisitely regulated by “writers,” “erasers,” and “readers,” additional repelled proteins or miRNAs, m6A modification relates to nearly any step of mRNA metabolism, as well as ncRNA processing and circRNA translation. There is compelling evidence suggesting that m6A modification is especially critical in a variety of pathologic and physiologic immune responses including T cell homeostasis and differentiation, inflammation, and type I interferon production. Further results have indicated that aberrancies of interferon and Th17 frequencies in systemic lupus erythematosus (SLE) patients may be caused by relevant genes changes for the altered m6A levels (79, 80). Whether functional dysregulations observed in SLE are associated with altered m6A modification warrants future exploration (81). Furthermore, m6A controls stem cell self-renewal, differentiation and pluripotency, additional critical functions in metabolism, as well as metastasis in many cancers (82), including acute myeloid leukemia, glioblastoma, breast cancer and lung carcinoma. Altered m6A modification might thus be an effective therapeutic target in preventing and treating human diseases. m6A exerts a variety of functions that result in alterations of particular functional proteins with m6A on mRNAs. Though the field of m6A modification has become increasingly attractive, serious challenges in research remain. More advanced technology will be ne...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Authors: Zhou S, Wei J, Wang Y, Liu X Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer-associated mortality worldwide. Despite clinical advances, the survival rate of patients with HCC remains low, as most patients are diagnosed with HCC when they are already at the advanced stage. Certain circular RNAs (circRNAs) are closely associated with the development of liver cancer. In the present study, a circRNA array was performed to screen differentially expressed circRNAs in HCC tissues. The further analysis focused on the newly identified circRNA_101237, the host gene of which, cyclin-dependent kin...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Li L, Zheng Y, Zheng Q, Jiang J Abstract The present study aimed to investigate the antiproliferative effect of embryonic stem cell-conditioned medium (ESC-CM) on the mouse liver cancer Hepa1-6 cells in vitro. Furthermore, in order to elucidate the underlying molecular mechanism, the microRNAs (miRNAs) in ESC-CM associated with the inhibition of Hepa1-6 proliferation were identified. Following the co-culture of ESC-CM and Hepa1-6 in Transwell chambers, the proliferation, cell cycle, apoptosis and associated protein expression were determined in Hepal-6 cells. Moreover, miRNA array analysis was employed to ...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Dolkhani S, Najafpour A, Mohammadi R Abstract Purpose: The improvement of techniques using conduits that connects the ends of damaged nerves and guides the growth of nerve fibers between the stumps, including adoption of natural or synthetic materials still is a challenge in peripheral nerve repair. The aim of the present novel study was to fabricate and transplant chitosan-selenium biodegradable nanocomposite conduit on transected sciatic nerve in rat model.Methods: In NORMAL group, the left sciatic nerve was exposed through a gluteal muscle incision and after careful hemostasis skin was closed. In TRANSE...
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
In spite of the recent approval of new promising targeted therapies, the clinical outcome of patients with acute myeloid leukemia (AML) remains suboptimal, prompting the search for additional and synergistic therapeutic rationales. It is increasingly evident that the bone marrow immune environment of AML patients is profoundly altered, contributing to the severity of the disease but also providing several windows of opportunity to prompt or rewire a proficient antitumor immune surveillance. In this Review, we present current evidence on immune defects in AML, discuss the challenges with selective targeting of AML cells, an...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Chengfeng Bai, Rongfang Xue, Jianbing Wu, Tian Lv, Xiaojun Luo, Yun Huang, Yan Gong, Honghua Zhang, Yihua Zhang, Zhangjian Huang To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Trump says personal protective gear has nearly run out; Florida, Georgia, Mississippi ordered to shelter in place; record daily fatalities in UK. Follow the latest updates.At a glance: summary of key eventsWimbledon cancelled due to coronavirus crisisAustralia coronavirus – latest updatesSee all of our coronavirus coverage5.54amBSTThe Chinese city of Shenzhen has banned the eating of dogs and cats as part of a wider clampdown on the wildlife trade since the emergence of the new coronavirus, Reuters reports.Scientists suspect the coronavirus passed to humans from animals. Some of the earliest infections were found in ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak UK news World news Science Infectious diseases Middle East and North Africa South Africa Russia China Japan Asia Pacific Europe Medical research Microbiology Source Type: news
NIEHS research on the virus aims to reveal structures suitable for targeted development of potential vaccines and treatments. (read more)
Source: Environmental Factor - NIEHS Newsletter - Category: Environmental Health Source Type: news
Bacteria in some tumors may hinder cancer treatments. (read more)
Source: Environmental Factor - NIEHS Newsletter - Category: Environmental Health Source Type: news
Publication date: Available online 1 April 2020Source: LinguaAuthor(s): Cai-Mei Yang, Tiao-Yuan Mao, Bing Bai
Source: Lingua - Category: Speech-Language Pathology Source Type: research
Opioid-involved drug overdose deaths have been a growing concern in the United States for several decades. The Centers for Disease Control and Prevention identified several strategies to address the opioid overdose epidemic, including increased availability of and access to medication-assisted treatment and guidance on safer opioid prescribing practices. Telehealth offers the potential for increasing access and availability to these strategies, and laws governing telehealth have implications for their utilization. To understand how state telehealth laws intersect with the opioid overdose epidemic, we conducted a legal mapp...
Source: Journal of Public Health Management and Practice - Category: Health Management Tags: Research Reports: Research Brief Report Source Type: research
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