Myeloid-Derived Suppressor Cells in Lung Transplantation

In conclusion, circulating MDSCs are measurable, functional and have a G-MDSC phenotype in lung transplant patients. Their frequency is increased in stable patients, decreased during post-transplant complications, and related to level of immunosuppression. This study may pave the way for further investigations of MDSC in the context of lung transplantation. Introduction From a transplant immunological point of view, graft acceptance is the fundamental element in allograft survival. Graft acceptance is realized by blocking the immune system with immunosuppression preventing host immune cells to recognized and attack the “non-self” donor (lung) tissue. Immune regulatory cells are thought to play a major role in the balance between graft acceptance and chronic rejection. Most attention has gone to natural and inducible FoxP3 positive regulatory T cells (Treg) (1). Immune regulation and graft acceptance, however, encompasses many more cells including regulatory B cells, regulatory dendritic cells and innate regulatory cells like the myeloid-derived suppressor cells (MDSCs), which were introduced 10 years ago by Gabrilovich et al., MDSCs were initially described as a heterogeneous group of immune cells from the myeloid lineage with a potent immune-regulatory activity (2). In the last few years, more insights into the nature and biological role of MDSCs have been reported and consequently MDSCs have emerged as a universal regulator of immune function in many pat...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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CONCLUSIONS: Esketamine is unlikely to be cost-effective for management of treatment-resistant depression in the United States unless its price falls by more than 40%. PMID: 32631129 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
This study was conducted to determine the in vitro activity of omadacycline against a large collection of patient isolate medical centers across Mainland China. A total of 1041 recent clinical isolates are obtained from patients hospitalized in 29 provinces and municipalities across China. The in vitro activity of omadacycline and comparator agents was assessed using the microbroth dilution methodology. Omadacycline was active against methicillin-susceptible and -resistantStaphylococcus aureus with MIC90 values of 0.25 and 1  mg/L, respectively. All isolates ofEnterococcus faecalis andEnterococcus faecium, including v...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
This study sought to discuss the correlation between the third-generation cephalosporins (3GC)-resistantEscherichia coli andKlebsiella pneumoniae and antibiotic consumption intensity from 143 Chinese tertiary hospitals in 2014. With a retrospective design, the correlation between antibiotic consumption and 3GC-resistantE. coli andK. pneumoniae were performed. 3GC-resistantE. coli was significantly correlated with the consumption of all antibiotics (r = 0.252,p 
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
AbstractIn vitro studies suggest that certain probiotic bacterial strains have potential activity against opportunistic infections such asCandida. There are few in vivo trials using probiotics as a single treatment for acuteCandida vulvovaginitis (CV). In this open-label, proof-of-concept study, selectedLactobacillus strains were tested in women with acuteCandida vaginitis. Twenty women diagnosed with proven, symptomatic CV were instructed to administer a vaginal probiotic gel withL. plantarum YUN-V2.0,L. pentosus YUN-V1.0 andL. rhamnosus YUN-S1.0 for 10 consecutive days. Vaginal rinsing fluid, vaginal culture swab and vag...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
AbstractHuman immunodeficiency virus (HIV) antibodies have been proposed as a measure of the size of the HIV reservoir. The aim of our study is to quantify the anti-HIV antibodies level in a cohort of people living with HIV (PLWH), stratified based on the presence of continuous undetectable HIV viral load and the co-existence of hepatitis C virus infection. A sample of 229 HIV-monoinfected (n = 114) or HIV/HCV-coinfected [either with resolved HCV infection (n = 75) or active HCV coinfection (n = 40)] patients, followed up a median of 34 (IQR 20–44) months, was studied. Anti-H...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
This study aimed at estimating the distributions of capsular polysaccharide (CPS) types and pilus profiles, and the rates of antimicrobial resistance among GBS strains isolated from colonized pregnant women and newborns in 2010 –2011 and 2017–2018 in St. Petersburg, Russia. A total of 261 GBS isolates have been investigated. Antibiotic susceptibility testing was performed using the disc-diffusion method. CPS types and pilus profiles were determined by using PCR. Over the 9-year period, the resistance of GBS to both ery thromycin and clindamycin has significantly increased, exceeding 30% in 2017–2018. The ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
AbstractRespiratory tract infections (RTI) can take a serious course under immunosuppression. Data on the impact of the underlying pathogens are still controversial. Samples from the upper (n = 322) and lower RT (n = 169) were collected from 136 children and 355 adults; 225 among them have been immunocompromised patients. Exclusion criteria were presence of relevant cultivable microorganisms, C-reactive protein>  20 mg/dl, or procalcitonin>  2.0 ng/ml. Samples were tested by PCR for the presence of herpesviruses (HSV-1/-2; VZV; CMV; HHV6; EBV), adenoviruses, bocavir...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Authors: Yang X, Wang H, Xie E, Tang B, Mu Q, Song Z, Chen J, Wang F, Min J PMID: 32632529 [PubMed - as supplied by publisher]
Source: Protein and Cell - Category: Cytology Tags: Protein Cell Source Type: research
Publication date: Available online 8 July 2020Source: Electronic Journal of BiotechnologyAuthor(s): Longxing Wang, Wenjun Zhu, Zhen Gao, Hua Zhou, Fei Cao, Min Jiang, Yan Li, Honghua Jia, Ping Wei
Source: Electronic Journal of Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 7 July 2020Source: Computational and Structural Biotechnology JournalAuthor(s): Shicai Liu, Jian Wu, Qiang Xia, Hongde Liu, Weiwei Li, Xinyi Xia, Jinke Wang
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
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