Analyses of the Global Multilocus Genotypes of the Human Pathogenic Yeast Candida tropicalis

Conclusion Our study revealed that the global population of C. tropicalis consists multiple genetic clusters with most of the clusters broadly distributed geographically. Our analyses showed that most observed genetic variations were found at local and regional levels and rejected the hypothesis that the global populations of C. tropicalis were structured based on geographic distances. Evidence for both medium- and long- distance dispersals was found. This study reaffirmed that the C. tropicalis MLST database provided a powerful platform not only for sharing strain and genotype information among investigators but also for helping us identifying broad epidemiological and population genetic patterns. Our analyses revealed several knowledge gaps from which future studies of C. tropicalis ecology, population genetics and molecular epidemiology could be focused on. Author Contributions J-YW retrieved and analyzed the data. JX guided the data analyses and drafted the manuscript. D-YZ, FM, and YZ participated in data analyses. All authors read and approved the manuscript. Funding The research in our labs on medical fungi are supported by grants from the National Natural Science Foundation of China (Grant No. 31860035), Natural Science Foundation of Hainan Province (20158374), the Education Department Foundation of Hainan Province (Hjkj2012-36), and the Natural Sciences and Engineering Research Council of Canada (CRDPJ 474638-14). Conflict of Interest Statement The authors dec...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research