HTLV-1 HBZ Protein Resides Exclusively in the Cytoplasm of Infected Cells in Asymptomatic Carriers and HAM/TSP Patients
In conclusion, we believe that the data presented in this research add new relevant information for a better definition of the pathological states associated with HTLV-1 infection, particularly in relation to the distinct subcellular expression of HBZ in the different pathological contests and related pathologies. Whether HBZ cytoplasmic and nuclear localization in the natural history of HTLV-1 infection represents a marker of infection or is part of the mechanism governing the evolution toward HAM/TSP or ATL is the challenge for future investigation. Author Contributions GF, MB, and RA conceived the work. GF, MB, and AT performed the experiments. All authors wrote, revised, and approved the final manuscript. Funding This research was supported by University of Insubria “FAR 2016 and 2017” (to RA and GF); by The Institutional Grant 2017, University of Insubria, to RA; and in part by European Community FP7 Grant no. 602893 “Cancer Vaccine Development for Hepatocellular Carcinoma-HepaVAC” http://www.hepavac.eu (to RA and GF). This research was also supported in part by the Intramural Research Program of the NINDS, NIH to SJ. The support of the NIH inpatient and outpatient neurology staff is acknowledged. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References Araya, N., Sato, T., Ando, H....
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SAN FRANCISCO - A groundskeeper whose $289 million award against Monsanto Co. was ultimately reduced to $78 million in his glyphosate cancer lawsuit filed a brief on Sept. 30 in a California appeals court contending that the court should disregard the attempts of various amici curiae to "inappropriately inject" new arguments and issues into the appeal (DeWayne Johnson v. Monsanto Company, Nos. A155940 and A156706, Calif. App., 1st Dist.).
SAN FRANCISCO - Monsanto Co. on Sept. 30 filed a brief in California appellate court contending that the U.S. Environmental Protection Agency has determined that glyphosate, the active ingredient in the herbicide Roundup, is not likely to cause cancer and, therefore, Roundup would be "misbranded" if it included a cancer warning (DeWayne Johnson v. Monsanto Company, Nos. A155940 and A156706, Calif. App, 1st Dist.).
SAN FRANCISCO - The circuit mediator for the Ninth Circuit U.S. Court of Appeals on Oct. 4 released from the mediation program two glyphosate cases against Monsanto Co. in which a cancer victim is appealing a district court judge's reduction of his original damages award against the company. Monsanto is cross-appealing the district court's denial of its motion for judgment notwithstanding the verdict (JNOV) (Edwin Hardeman v. Monsanto Company, No. 19-16636, 9th Cir.).
ST. LOUIS - A state court judge in Missouri on Oct. 4 postponed indefinitely a cancer victim's lawsuit against Monsanto Co. related to the herbicide Roundup, which contains the active ingredient glyphosate (Walter Winston v. Monsanto Company, No. 1822-CC00515, Mo. Cir., St. Louis City).
WEST PALM BEACH, Fla. - Lowe's Home Centers LLC in an Oct. 4 answer tells a Florida federal court that it has not violated any laws by selling the herbicide Roundup, which contains the ingredient glyphosate, and it denies that glyphosate-containing products cause cancer (Yvette Helen Biddle v. Lowe's Home Centers LLC, No. 19-81251, S.D. Fla.).
CHARLESTON, S.C. - A charity and a water supplier on Oct. 4 moved in South Carolina federal court for permission to amend their complaint against the United States related to groundwater contamination from aqueous film forming foam (AFFF) to add claims against new parties including the 3M Co., Tyco Fire Products LP and others (Security Water District, et al. v. United States of America [In re: Aqueous Film Forming Foam], No. 19-2187, MDL 18-2873, D. S.C.).
Authors: Günal A, Pekçetin S, Demirtürk F, Şenol H, Håkansson C, Wagman P Abstract Background: Occupational balance (OB) is an important concept in occupational therapy and is considered as an essential component of health and well-being. Aim: The aim of this study was to investigate the validity and reliability of the Turkish version of the Occupational Balance Questionnaire-11 (OBQ11-T). Materials and methods: The OBQ11-T was administered to 116 individuals for construct validity analysis and to 58 individuals for reliability analysis. Validity was determined using explanatory and confirma...
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