Dual roles of IL-18 in colitis through regulation of the function and quantity of goblet cells.

In conclusion, IL‑18 served a dual function in colitis by regulating the function of goblet cells. The anti‑inflammatory effects of IL‑18 were observed in the early stage of colitis‑induced inflammation, while the pro‑inflammatory effects were observed in the later stages of the disease.
PMID: 31017261 [PubMed - in process]

Source: International Journal of Molecular Medicine - April 26, 2019 Category: Molecular Biology Authors: Pu Z, Che Y, Zhang W, Sun H, Meng T, Xie H, Cao L, Hao H Tags: Int J Mol Med Source Type: research