Long-Term Endurance and Power Training May Facilitate Motor Unit Size Expansion to Compensate for Declining Motor Unit Numbers in Older Age

Long-Term Endurance and Power Training May Facilitate Motor Unit Size Expansion to Compensate for Declining Motor Unit Numbers in Older Age M. Piasecki1*, A. Ireland2, J. Piasecki3, H. Degens2,4, D. W. Stashuk5, A. Swiecicka6, M. K. Rutter6,7, D. A. Jones2 and J. S. McPhee8,9* 1Clinical, Metabolic and Molecular Physiology, MRC-ARUK Centre for Musculoskeletal Ageing Research, National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom 2School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom 3Musculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom 4Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, Lithuania 5Department of Systems Design Engineering, University of Waterloo, Waterloo, ON, Canada 6Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom 7Manchester Diabetes Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom 8Department of Sport and Exercise Sciences, Musculoskeletal Science and Sports Medicine Research Centre, Manchester Metropolitan University, Manchester, Unit...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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CONCLUSIONS: Our findings support the protective effect a normal weight against advanced adenomas. Reduction of BMI value should be pursued in healthy programs. PMID: 32233893 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Conclusion: There is a slightly increasing trend in the occurrence of esophageal perforations. Contemporary treatment is less invasive with similar results. Patients treated in high-volume hospitals have better prognosis. PMID: 32233883 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Conclusion: Abstinence from alcohol following AC/AH diagnosis was achieved in 39% of patients. Abstinence was not related to increased survival for alcoholic liver disease patients at one-year, which might partly indicate that this might be a marker that some patients were 'too sick to drink'. AC and AH patients who survived one year and remained abstinent had a favorable long-term prognosis. PMID: 32233877 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Authors: Møller S, Kimer N, Barløse M, Bendtsen F Abstract Detailed knowledge and understanding of the pathophysiological mechanisms and changes in hepatic and splanchnic function leading to the development of haemodynamic changes and portal hypertension in patients with cirrhosis are essential since it guides the search for targets to ameliorate liver-related abnormalities. Recent research has focused on the gut-liver axis, changes in intestinal permeability, translocation of bacterial products, and inflammation as important drivers of haemodynamic alterations and thereby targets for treatment. Addit...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Authors: Freitas M, Arieira C, Carvalho PB, Rosa B, Moreira MJ, Cotter J Abstract Background: Capsule endoscopy is a widely recognized method to study the small bowel, including in patients with Crohn's disease (CD). The Lewis score (LS) is a valuable tool in this setting, able to assess inflammatory activity. TOP100, a new software tool of the RAPID Reader®, emerged to assist in the time-consuming capsule reading process, by automatically selecting 100 images that will most likely contain abnormalities.Aim: Evaluate the agreement between TOP100 and classic reading (CR) in determining LS in the setting of CD.Me...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Publication date: 12 April 2020Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 30, Issue 4Author(s): Huanhuan Wang, Ying Song, Xiaofang Tang, Jingjing Xu, Ping Jiang, Lin Jiang, Zhan Gao, Jue Chen, Lei Song, Yin Zhang, Xueyan Zhao, Shubin Qiao, Yuejin Yang, Runlin Gao, Bo Xu, Jinqing Yuan, Lijian Gao
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Abstract PET and SPECT provide us with information about biological quantitative values at localized area, even at the deep component of human. They usually have been used for diagnosis, but when combining with radiotherapy, PET and SPECT images would be helpful to make a decision on radiation-dose distribution for treatment because the patient images can be obtained in the similar condition under radiation therapy. In addition, anti-tumor effect of radiation therapy is now precisely controlled for target. Therefore, precise information of tumor, such as extent of tumor and heterogeneity within tumor, would make t...
Source: Igaku Butsuri: Japanese Journal of Medical Physics - Category: Physics Authors: Tags: Igaku Butsuri Source Type: research
Authors: PMID: 32238687 [PubMed - as supplied by publisher]
Source: Igaku Butsuri: Japanese Journal of Medical Physics - Category: Physics Tags: Igaku Butsuri Source Type: research
We reported a sporadic case of olanzapine-induced rapid-onset Type 2 diabetes with severe hyperglycemia.2 In our case, the patient was negative for anti-glutamic acid decarboxylase antibodies, and the discontinuation of olanzapine and careful insulin replacement regimen reversed diabetes. A common feature between these two cases is acute-onset severe hyperglycemia. The first presentation of diabetes associated with olanzapine might be diabetic ketoacidosis (DKA), requiring admission to an intensive care unit. Patients exposed to antipsychotics have approximately 10 times increased risk of DKA compared to the general popula...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Letters to the Editor Source Type: research
Conclusions and Relevance: In this Danish nationwide study to investigate the association between diabetes and ALS diagnosis, our findings are in agreement with previous reports of a protective association between vascular risk factors and ALS and suggest that type 2 diabetes, but not type 1, is protective for ALS. PMID: 26030836 [PubMed - as supplied by publisher]
Source: Cancer Control - Category: Cancer & Oncology Authors: Tags: JAMA Neurol Source Type: research
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