Mandibular Vertical Growth Deficiency After Botulinum-Induced Hypotrophy of Masticatory Closing Muscles in Juvenile Nonhuman Primates

This study was approved by the Animal Experimental Ethics Committee of Southern Medical University, Guangzhou, China (2014-024). All experiments were performed under protocols to meet the requirements of the Association for Assessment and Accreditation of Laboratory Animal Care International and the Experimental Animal Center of Southern Medical University. Male cynomolgus monkeys (Macaca fascicularis) were used, preliminary power analysis being performed to get the proper sample size for three groups (G∗Power 3.1, Heinrich-Heine-Universität Düsseldorf, Germany; alpha = 0.05, power = 0.95; total N = 20 hemi-mandibles). They had complete deciduous dentitions and first permanent molars in occlusion, indicating their juvenile period (McNamara and Graber, 1975). The animal care was performed by full-time attending veterinarians under the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. The animals were housed individually in stainless steel cages (85 cm × 92 cm × 100 cm) under a 12 h light-dark cycle at 25–27°C. They were provided with a diet of vitamin enriched biscuits, fruits, and water until they were satisfied. They were also provided with social interactions with neighboring animals and attending veterinarians and given toys and trees for play stimulation. During all experimental periods, they were closely monitored on a regular basis throughout the day by the attending veterinarians as well as th...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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ConclusionGiven our findings, conservative treatment should be compared to surgical treatment for displaced fractures and the anterior approach should be compared to the posterior one for surgical cases.Level of evidenceIV.
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
CONCLUSIONS: For peripheral lung cancer, the measurement on CT and routine MRI sequences can potentially replace each other after comprehensive consideration of examination purposes, but for central lung cancer, alternative use of CT and MRI in evaluating treatment responses for lung cancer should needs extra attention. The diameter measurement of lung cancer on DWI is consistent with that on T1WI and T2WI, suggesting that DWI can provide functional and morphological information. PMID: 32083610 [PubMed - as supplied by publisher]
Source: Journal of X-Ray Science and Technology - Category: Radiology Tags: J Xray Sci Technol Source Type: research
Authors: Merrigan SL, Park B, Ali Z, Jensen LD, Corson TW, Kennedy BN Abstract Aberrant ocular angiogenesis can underpin vision loss in leading causes of blindness, including neovascular age-related macular degeneration and proliferative diabetic retinopathy. Current pharmacological interventions require repeated invasive administrations, may lack efficacy and are associated with poor patient compliance and tachyphylaxis. Vitamin D has de novo anti-angiogenic properties. Here, our aim was to validate the ocular anti-angiogenic activity of biologically active vitamin D, calcitriol, and selected vitamin D analogue, 2...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Carey RM, Rajasekaran K, Seckar T, Lin X, Wei Z, Tong CCL, Ranasinghe VJ, Newman JG, O'Malley BW, Weinstein GS, Feldman MD, Robertson ES Abstract Oropharyngeal squamous cell carcinoma (OPSCC) represents the most common HPV-related malignancy in the United States with increasing incidence. There is heterogeneity between the behavior and response to treatment of HPV-positive oropharyngeal squamous cell carcinoma that may be linked to the tumor virome. In this prospective study, a pan-pathogen microarray (PathoChip) was used to determine the virome of early stage, p16-positive OPSCC and neck metastasis treate...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
ConclusionsCardiac effects after severe late-onset PE were small and transient. This indicates that left ventricular hypertrophy after severe late-onset PE may be a secondary physiologic response to increased peripheral resistance in PE. Vascular mechanisms rather than persistent cardiac hypertrophy postpartum may be the culprit for increased long-term cardiovascular risk after PE.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
ConclusionWe feel these data are suggestive of increased on-aspirin platelet (re-)activity, as measured by the PFA-200 and the VerifyNow, in non-pregnant carriers of a FII-mutation, but not in carriers of FVL-mutation. Interestingly, this increased on-aspirin platelet (re-)activity is present in spite of low sTxB2 levels.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Publication date: 9 March 2020Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 30, Issue 3Author(s): G. Pagliai, M. Dinu, B. Colombini, N. Pini, L. Granchi, F. Sofi
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: 9 March 2020Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 30, Issue 3Author(s): G. Pagliai, M. Dinu, B. Colombini, A. Whittaker, S. Benedettelli, G. Ballerini, F. Sofi
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: 9 March 2020Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 30, Issue 3Author(s): C. Montagnese, G. Porciello, S. Vitale, E. Palumbo, I. Calabrese, A. Crispo, M. Grimaldi, R. Pica, V. Marotta, N. Esindi, M. Prete, S. Cubisino, L. Falzone, M. De Laurentiis, M. Rinaldo, M. D’Aiuto, D. Cianniello, C. Pacilio, M. Pinto, G. Thomas
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: 9 March 2020Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 30, Issue 3Author(s): F. Fiori, F. Concina, P. Gnagnarella, G. Carioni, M. Parpinel
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
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