Endothelium-dependent Hyperpolarization-Mediated Relaxation Pathway in Bovine Mesenteric Lymph Nodes.

Endothelium-dependent Hyperpolarization-Mediated Relaxation Pathway in Bovine Mesenteric Lymph Nodes. Dokl Biol Sci. 2019 May;484(1):10-12 Authors: Lobov GI, Dvoretskii DP Abstract Endothelium-dependent relaxation mechanisms have been studied in phenylephrine-precontracted capsules of bovine mesenteric lymph nodes studied in vitro. Tetraethylammonium chloride and TRAM-34 in a solution with L-NAME and Indomethacin, which suppress the production NO and prostacyclin of endothelium, increased the tone of the lymph nodes. We believe that in bovine mesenteric lymph nodes, the dilation mechanism is mediated by hyperpolarization of the endothelium, which is associated with activation of large- and intermedium conductance Ca2+-activated potassium channels. PMID: 31016496 [PubMed - in process]
Source: Doklady Biological Sciences - Category: Biology Authors: Tags: Dokl Biol Sci Source Type: research