Decreased insulin sensitivity and abnormal glucose metabolism start in preadolescence in low-birth-weight children —Meta-analysis and systematic review

Many researchers have focused on the relationship between low birth weight (LBW) and adult diabetes [1 –3]. Studies showed that the risk of insulin resistance and diabetes was higher in small-for-gestational-age (SGA) or LBW people [1–3]. Some meta-analyses have examined birth weight and late-onset diabetes, not early-onset diabetes. However, glucose abnormalities can start in adolescence and res ult in early-onset diabetes [4,5]. Moreover, compared to late-onset diabetes, early-onset diabetes worsens quality of life and health with more complications, higher disability rate and mortality [6].

Source: Primary Care Diabetes - April 24, 2019 Category: Primary Care Authors: Yiwen Xu, Shi Chen, Hongbo Yang, Fengying Gong, Linjie Wang, Yu Jiang, Chengsheng Yan, Huijuan Zhu, Hui Pan Tags: Review Source Type: research