Effects of Aerobic Exercise as Add-On Treatment for Inpatients With Moderate to Severe Depression on Depression Severity, Sleep, Cognition, Psychological Well-Being, and Biomarkers: Study Protocol, Description of Study Population, and Manipulation Check

Conclusions: Overall, patients showed good adherence to the intervention protocol despite at least moderate depression severity. However, the dropout rate suggests that depressed inpatients may need special support to adhere to a structured exercise intervention program. This study will add evidence on the effects of AE as an add-on to inpatient treatment of moderate to severe depression. Besides antidepressant effects, potentially beneficial effects of AE on a broad array of further variables associated with depression will be evaluated.Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT02679053.IntroductionAccording to the World Health Organization (WHO), unipolar depression is considered the most disabling condition concerning disability-adjusted life years in middle- to high-income countries (1). Of all brain disorders, depression causes the highest economic burden in Switzerland (2). With approximately 30% of depressed patients meeting criteria for treatment-resistant depression (3) and a lack of new pharmacological targets besides the well-known monoaminergic compounds, there is a need for new treatment strategies for depression.Aerobic exercise (AE) may be one such a strategy as it has proven to be an effective treatment for mild to moderate depression in several meta-analyses with small to moderate effect sizes (4, 5). However, if AE is compared to a comparator–intervention and if only methodologically sound studies are included in the pooled anal...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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Publication date: Available online 20 October 2019Source: International Journal of PsychophysiologyAuthor(s): Eliana Vassena, Filip Van Opstal, Ingeborg Goethals, Tom VergutsAbstractThe ability to exert control has been widely investigated as a hallmark of adaptive behaviour. Dopamine is recognized as the key neuromodulator mediating various control-related processes. The neural mechanisms underlying the subjective perception of being in control, or Locus of Control (LOC) are however less clear. LOC indicates the subjective tendency to attribute environmental outcomes to one's actions (internal LOC) or instead to external ...
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research
Objective: To compare the rate of malreduction after high fibular fractures associated with syndesmosis injury treated with open reduction and internal fixation, with either 2 screws or 1 knotless TightRope device. Design: Prospective randomized controlled multicenter trial. Setting: Eleven academic and community hospitals including Level 1 and Level 2 trauma centers across Canada. Patients/Participants: One hundred three patients with OTA/AO 44-C injuries with demonstrated radiographic syndesmosis diastasis or instability after malleolar bony fixation were followed for 12 months after treatment. Methods: Ope...
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
Conclusions: Results suggest TCC may have a small positive effect on early outcomes, but use of the services was highly variable among sites. Level of Evidence: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
Conclusions: Three thousand eight hundred ten articles were identified, and 12 met inclusion criteria. These studies encompassed 497 patients with an average age of 14.1 years (8–18 years, range). Both operative and nonoperative management of displaced midshaft clavicle fractures in this population provide excellent rates of union and patient-reported outcome measures. Compared with nonoperative management, operative management yielded faster return to activity, superior Constant scores, and equal QuickDASH scores. Operative management had higher complication rates and complications that required secondary operativ...
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Review Article Source Type: research
This study explored the association between serum vitamin D levels and urinary tract infections in pregnant women.Study designIn this case control study, 187 participants including, 97 pregnant women diagnosed as a symptomatic UTI (case group) and 90 matched healthy pregnant women (control group) were consecutively enrolled from prenatal care clinic of Imam Reza Hospital in Urmia, North West of Iran. The two groups were matched for trimester and parity, and sexual intercourse. Blood samples were collected from both groups. Chemiluminescent immunoassay (CLIA) was used to evaluate the serum vitamin D levels. We used a binary...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
STOMACH bloating is usually remedied by making simple dietary changes. If quick fixes do not alleviate the tummy swelling, this may signal a more serious condition, including one that specifically affects women.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
ConclusionsNon-motor symptoms are independent of motor features and likely belong to the clinical spectrum of blepharospasm. The presence of non-motor symptoms possibly reflects a complex network disorder of blepharospasm.
Source: Journal of Neurology - Category: Neurology Source Type: research
AbstractEpilepsy self-management practices enhance a patient ’s competence and confidence in managing their chronic condition, which is assumed to lead to an improved quality of life (QoL). We analyzed the relationship between the Epilepsy Self-Management Scale (ESMS) responses and the Quality of Life in Epilepsy (QOLIE-31) scores. Baseline questionnaires f rom HOBSCOTCH, a self-management program for cognitive problems, were administered in four New England epilepsy centers on adults (n = 100) with epilepsy and subjective memory complaints. There was no correlation between overall self-management score...
Source: Journal of Neurology - Category: Neurology Source Type: research
Swedish DJ Tim Bergling, or Avicii, revolutionized electronic dance music and collaborated with many of the world's top artists. In April 2018, Bergling died by suicide while on vacation in Oman. He was 28. After his death, his parents started the Tim Bergling Foundation to advocate for the recognition of suicide as a global health emergency and to remove the stigma of mental illness. Father  Klas Bergling spoke with "CBS This Morning" co-host Anthony Mason in his first U.S. broadcast interview.
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
Source: BMJ News - Category: General Medicine Source Type: research
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