Attenuation of Multiple Vibrio parahaemolyticus Virulence Factors by Citral

Conclusions In conclusion, this investigation indicated that citral attenuated multiple virulence factors of V. parahaemolyticus, including QS, motility, biofilm formation, the adhesion to Caco-2 cells, and repressed the expression of genes related to flagella (polar and lateral), biofilm and T3SS1 effectors, virulence regulators (luxS, aphA and toxR), and AMP resistance. The results obtained in this work demonstrate the inhibitory effect of citral on virulence factors of V. parahaemolyticus. However, the data reported in this study only demonstrate the anti-virulence effect of citral in vitro. Further research is needed to clarify the mode of the anti-virulence action of citral and to investigate its effects in experimental animal models, aiming toward the application of citral as an alternative strategy to control the infections of V. parahaemolyticus. Author Contributions CS and YS conceived and designed the experiments. DG, ZH and HS performed the experiments. ZZ analyzed the data. XX contributed reagents, materials, and analysis tools. YS and CS wrote the manuscript. Funding This work was supported by the Fundamental Research Funds for the Central Universities (2452017228); National Natural Science Foundation of China (31772084); and General Financial Grant from the China Postdoctoral Science Foundation (2017M623256). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationsh...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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Diseases and disorders such as Parkinson disease, schizophrenia, and chronic pain are characterized by altered mesolimbic dopaminergic neurotransmission. Dopamine release in the nucleus accumbens influences behavior through both tonic and phasic signaling. Tonic dopamine levels are hypothesized to inversely regulate phasic signals through dopamine D2 receptor feedback inhibition. We tested this hypothesis directly in the context of ongoing pain. Tonic and phasic dopamine signals were measured using fast-scan controlled-adsorption voltammetry and fast-scan cyclic voltammetry, respectively, in the nucleus accumbens shell of ...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
This study describes our experience with 4 preparatory protocols used in our institution.MethodsFDG PET/CT scans were performed according to 4 preparatory protocols (716 scans total), i.e. 6-h fast (group 1), low-carbohydrate diet plus 12-h fast (group 2), low-carbohydrate diet plus 12-h fast plus intravenous heparin pre-administration (15  IU/kg) (group 3), and low-carbohydrate diet plus 12-h fast plus intravenous heparin pre-administration (50 IU/kg) (group 4). Consecutive scans were retrospectively included from time frames during which the particular protocol was used. FDG uptake in normal myocardium was scor...
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
ConclusionDespite the restrictive medical measures for the emergency, the number of FDG-PET/CT studies was unchanged during the pandemic compared with the previous year. Our findings also indicate that Covid-19 infection was contained in our series of patients from southern Italy.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
ConclusionThe total-body PET/CT can significantly shorten the acquisition time with maintained lesion detectability and image quality.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
ConclusionChest CT combined with analysis by the uAI Intelligent Assistant Analysis System can accurately evaluate pneumonia in COVID-19 patients.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
ConclusionWe present a FA approach for IDIF extraction which is robust, reproducible and can be used in quantification methods for resolution recovery, denoising and parameter estimation. We demonstrated that the proposed quantification method yields parameter estimates closer to ex vivo measurements than semi-quantitative methods such as %ID and is immune to tracer binding in tissue unlike reference tissue methods. This approach allows for accurate quantification in longitudinal PET studies in mice while avoiding repeated blood sampling.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Publication date: Available online 22 September 2020Source: Materials Today: ProceedingsAuthor(s): J. Somasekar, P. Pavan Kumar Visulaization, Avinash Sharma, G. Ramesh
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
[Malaria Consortium] When COVID-19 was declared a pandemic by WHO in March 2020, governments and organisations involved in the prevention and control of malaria had a choice to make - divert their attention from the diagnosis, control and prevention of malaria to that of COVID-19, or leverage the existing surveillance systems to fight both as effectively as possible.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
Authors: Upadhya P, Vadala R, A A Abstract Patients of chronic obstructive pulmonary disease (COPD) during COVID-19 pandemic have higher morbidity. Treatment of these patients require aerosolization procedures like nebulization and noninvasive modalities for ventilation like non-invasive ventilation (NIV) and high flow nasal cannula (HFNC). Role of these procedures in corona virus transmission when treating a case of acute exacerbation of chronic obstructive pulmonary disease should be further studied. PMID: 32960000 [PubMed - as supplied by publisher]
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
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