Attenuation of Multiple Vibrio parahaemolyticus Virulence Factors by Citral

Conclusions In conclusion, this investigation indicated that citral attenuated multiple virulence factors of V. parahaemolyticus, including QS, motility, biofilm formation, the adhesion to Caco-2 cells, and repressed the expression of genes related to flagella (polar and lateral), biofilm and T3SS1 effectors, virulence regulators (luxS, aphA and toxR), and AMP resistance. The results obtained in this work demonstrate the inhibitory effect of citral on virulence factors of V. parahaemolyticus. However, the data reported in this study only demonstrate the anti-virulence effect of citral in vitro. Further research is needed to clarify the mode of the anti-virulence action of citral and to investigate its effects in experimental animal models, aiming toward the application of citral as an alternative strategy to control the infections of V. parahaemolyticus. Author Contributions CS and YS conceived and designed the experiments. DG, ZH and HS performed the experiments. ZZ analyzed the data. XX contributed reagents, materials, and analysis tools. YS and CS wrote the manuscript. Funding This work was supported by the Fundamental Research Funds for the Central Universities (2452017228); National Natural Science Foundation of China (31772084); and General Financial Grant from the China Postdoctoral Science Foundation (2017M623256). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationsh...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
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Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
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Source: IDCases - Category: Infectious Diseases Source Type: research
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Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
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Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
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Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
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