Attenuation of Multiple Vibrio parahaemolyticus Virulence Factors by Citral
Conclusions In conclusion, this investigation indicated that citral attenuated multiple virulence factors of V. parahaemolyticus, including QS, motility, biofilm formation, the adhesion to Caco-2 cells, and repressed the expression of genes related to flagella (polar and lateral), biofilm and T3SS1 effectors, virulence regulators (luxS, aphA and toxR), and AMP resistance. The results obtained in this work demonstrate the inhibitory effect of citral on virulence factors of V. parahaemolyticus. However, the data reported in this study only demonstrate the anti-virulence effect of citral in vitro. Further research is needed to clarify the mode of the anti-virulence action of citral and to investigate its effects in experimental animal models, aiming toward the application of citral as an alternative strategy to control the infections of V. parahaemolyticus. Author Contributions CS and YS conceived and designed the experiments. DG, ZH and HS performed the experiments. ZZ analyzed the data. XX contributed reagents, materials, and analysis tools. YS and CS wrote the manuscript. Funding This work was supported by the Fundamental Research Funds for the Central Universities (2452017228); National Natural Science Foundation of China (31772084); and General Financial Grant from the China Postdoctoral Science Foundation (2017M623256). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationsh...
ConclusionIP is a diagnosis of exclusion which should only be made after surgical and non-surgical causes have been outruled. In the absence of signs of peritonitis and evidence of gastrointestinal perforation on CT, a conservative approach is warranted, allowing patients to avoid unnecessary surgical intervention.
ConclusionsWe present the rare case of a patient with surgically resected locally advanced rectal cancer who demonstrated an impressive pCR with preoperative chemotherapy, which included FOLFOX plus bevacizumab.
CONCLUSIONTc-99 m SC SPECT-CT is a novel helper used to assess the differential liver function after Y90 radioembolization of HCC and before segmentectomy and lobectomy of the liver.
Authors: Bilezikian JP, Hattersley G, Mitlak BH, Hu MY, Fitzpatrick LA, Dabrowski C, Miller PD, Papapoulos SE Abstract Objective: To evaluate, post hoc, the efficacy and safety of abaloparatide by degree of renal impairment. Methods: ACTIVE was a phase 3, 18-month, randomized, double-blind, active-comparator, placebo-controlled study of postmenopausal women with osteoporosis who received subcutaneous abaloparatide 80 µg, placebo, or open-label teriparatide 20 µg daily. Patients with serum creatinine>2.0 mg/dL or 1.5-2.0 mg/dL with an estimated glomerular filtration rate (eGFR)
ConclusionsTo prevent students from experiencing demotivation, teachers in the nursing faculty need to manage learning resources more effectively, create a quiet and focused atmosphere to allow students to concentrate, and be enthusiastic about teaching. They also need to add value to their classes, help students to follow lectures, and ensure that the workload they give their students is appropriate.
ConclusionsDespite previous reports in Argentina, ST258 is no longer the absolute clone among KPC-Kp isolates. In the present study, dissemination of more virulent lineages such as the hypermucoviscous ST25 was detected. The emergence of the high-risk clone ST307 and occurrence of blaKPC-3 was noticed for the first time in this region.
Publication date: Available online 17 August 2019Source: IDCasesAuthor(s): Mohamadreza Salehi, Sahar Shadvar, Mohammad Sadeghian, Mahsa Doomanlou, Alireza Abdollahi, Seyed Ali Dehghan Manshadi, Akram Sardari, Hossein Ali Rahdar, Mohammad Mehdi FeizabadiAbstractAeromonas salmonicida (A. salmonicida) is a facultative Gram-negative bacillus, inhabiting in water. It is a common source of furunculosis and septicemia in fish. Report on the human infection with this organism is rare. A male farmer referred with weakness and intermittent fever. He had cardiac valves’ regurgitation due to fever with rheumatic heart disease. H...
ConclusionsThis study suggests that chronic respiratory diseases and shortness of breath are independent risk factors for influenza B virus–associated pneumonia in adult patients.
Publication date: Available online 18 August 2019Source: Alzheimer's &DementiaAuthor(s): Binyin Li, Yixi He, Jianfang Ma, Pei Huang, Juanjuan Du, Li Cao, Yan Wang, Qin Xiao, Huidong Tang, Shengdi ChenAbstractObjectiveGut microbiota changes before the onset of Alzheimer's disease (AD) and the alterations could be detected in the stage of mild cognitive impairment (MCI). The findings might offer diagnostic biomarkers before the onset of dementia.BackgroundAD is the most common cause of dementia, and MCI is the predementia state. Recent studies suggest the alterations in the gut microbial communities associated with AD, w...
An unnamed Novartis executive sold 925,400 Swiss francs ($946,000) worth of shares less than three weeks before the U.S. Food and Drug Administration (FDA) announced data from tests of its gene therapy Zolgensma had been manipulated.
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