The immunomodulatory role of sodium.

[The immunomodulatory role of sodium]. Orv Hetil. 2019 Apr;160(17):646-653 Authors: Agócs RI, Sugár D, Pap D, Szabó AJ Abstract High salt intake, which is common in the Western world, is the cause of several lifestyle diseases. Recent investigations shed light on novel extrarenal processes, which play role in the maintenance of sodium balance. In the short term, sodium storage of the skin may serve as a buffer against volume overload arising from the osmotic properties of sodium. Increased tissue sodium concentration may also potentiate immune response against infections. In the long run, however, tissue sodium concentration over a certain limit may initiate pathophysiological processes by provoking inflammatory response. Due to the immune modulating role of sodium, the effector cells of the innate as well as the adaptive immune system are activated, while certain regulator cells of the same systems are repressed, ultimately resulting in a proinflammatory state characterized by the imbalance of the immune system. Experiments applying dietary salt overload/salt depletion imply the role of sodium in the initiation/exacerbation of several diseases. Thus the relationship between sodium and the immune system may give an explanation to the pathomechanism of diseases with so far unknown origin such as hypertonia (primary, salt sensitive) or autoimmune diseases - all these putting tremendous pressure on the healthcare system due to their inc...
Source: Orvosi Hetilap - Category: General Medicine Authors: Tags: Orv Hetil Source Type: research

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Conclusion: Outcomes of w-AIHA treatment were considerably heterogeneous. Low rituximab doses plus high dexamethasone doses were effective for refractory disease. PMID: 31309092 [PubMed]
Source: Blood Research - Category: Hematology Tags: Blood Res Source Type: research
Publication date: Available online 16 July 2019Source: Autoimmunity ReviewsAuthor(s): Marina Mané-Damas, Carolin Hoffmann, Shenghua Zong, Amanda Tan, Peter C. Molenaar, Mario Losen, Pilar Martinez-MartínezAbstractPsychotic disorders are debilitating mental illnesses associated with abnormalities in various neurotransmitter systems. The development of disease-modifing therapies has been hampered by the mostly unknown etiologies and pathophysiologies.Autoantibodies against several neuronal antigens are responsible for autoimmune encephalitis. These autoantibodies disrupt neurotransmission within the brain, resu...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
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Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Publication date: Available online 16 July 2019Source: Autoimmunity ReviewsAuthor(s): Huahua Zhong, Chongbo Zhao, Sushan LuoAbstractMyasthenia gravis (MG) is a rare autoimmune disease characterized by muscle weakness and abnormal fatigability. Like many other autoimmune diseases, genetic contribution to MG has been studied where the HLA system appears to play the most vital role. Although many correlations have been revealed in these studies, the underlying mechanism for them is still in the veil. Based on current evidence, we propose two synergetic mechanisms underlying the MG predisposition via HLA. In brief, the first a...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Conditions:   Vasculitis;   Systemic Lupus Erythematosus;   Myositis Intervention:   Other: ICU Care Sponsors:   University of Göttingen;   University Medical Center Goettingen Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Nozue T, Toyoshima M, Fukada A, Suda T Abstract A 71-year-old woman with congenital rubella syndrome (CRS) presented with prolonged cough. No physical findings suggested the presence of any connective tissue diseases. Chest computed tomography showed ground-glass opacities and consolidations in the bilateral lower lobes. She had elevated serum Krebs von den Lungen-6, hypoxemia and positive serum anti-Jo-1 antibody. Bronchoalveolar lavage fluid revealed lymphocytosis with a decreased CD4/CD8 ratio. A transbronchial lung biopsy specimen revealed organizing pneumonia. Based on a diagnosis of interstitial pneu...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
ConclusionsSeveral circulating lymphocyte subpopulations in patients with ISM were significantly different when compared to healthy controls; and in specific lymphocyte subsets, this lymphocyte skewing correlated with clinical observations including osteoporosis and autoimmune disease. These data suggest the need for further studies on abnormalities in lymphocyte subsets and the attendant clinical consequences in both mast cell proliferative and activation disorders.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 15 July 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): M. Autran-Martínez, P. Cortes-Acevedo, L. Cerón-Gutiérrez, S. Davies, Elvira S. Mendoza, H.A. Martínez-Rodríguez, C. Liboni, V. Pérez-Valencia, R. Döffinger, G. Barcenas-MoralesAbstractAutoantibodies against cytokines have been associated with immunodeficiency, susceptibility to infectious diseases, autoimmunity and inflammation in humans, but have not yet been investigated in the Veterinary field so far. The aim of the current study was to determine the presence of anti-...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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