Systematic Evaluation of the Safety Threshold for Allograft Macrovesicular Steatosis in Cadaveric Liver Transplantation

Conclusions: The threshold of allograft MaS content can be safely extended to 35% without additional risk burden on post-transplant inferior outcomes. Clarification on “the effects of stratification” for MaS content can provide theoretical evidence for further optimal utilization of marginal steatotic allografts in liver transplantation. Introduction Liver transplantation (LT) is still the most effective strategy for treatment of end-stage liver disease, hepatobiliary carcinoma, and acute/chronic liver failure. Currently, organ shortage is prominent in view of the contradiction between the limited donor pool and the ongoing increasing demand for liver allografts from patients registered on waiting lists (Lucidi et al., 2015). A steatotic allograft is one of the most commonly used marginal donors in clinical practice (McCormack et al., 2011), but affects the prognosis in >30% of patients who undergo liver transplantation (McCormack et al., 2011). Given the global epidemic of non-alcoholic fatty liver disease (Younossi et al., 2018) and the increase in organs from older donors (Halazun et al., 2018), the impact of steatotic grafts on transplantation cases is an inevitable issue. Fatty infiltration amplifies the susceptibility to primary non-function (PNF) and early allograft dysfunction (EAD) (McCormack et al., 2011; Deschenes, 2013); however, adverse events associated with implants have been presented inconsistently as a result of variance in pat...
Source: Frontiers in Physiology - Category: Physiology Source Type: research