Constant-Moderate and High-Intensity Interval Training Have Differential Benefits on Insulin Sensitive Tissues in High-Fat Fed Mice

Conclusion In summary, our data suggests that when END and HIIT are designed to be equivalent in terms of distance covered, timing per session, and average intensities, similar effects can be seen in the metabolic function of skeletal muscle, white adipose tissue, and liver. Interestingly, these changes are independent of variations in body weight or body composition. Nevertheless, HIIT seems to induce further benefits on the level of adiponectin receptors in skeletal muscle and the browning of white adipose tissue, whereas END is more effective in protecting the liver ECM against disturbances induced by HFD (Figure 12). This indicates that different exercise prescriptions may provide favorable outcomes to different insulin sensitive tissues, a finding that with time will likely be considered when physical exercise is prescribed to manage metabolic disturbances associated with obesity. Future studies that explore the mechanisms behind these differential benefits would further clarify the differential outcomes described in this study. Ethics Statement This study was approved by the University of Sydney Animal Ethics Committee (Protocol #2015/816). The experiments described herein were carried out according to the guidelines laid down by the New South Wales Animal Research Act and the 8th Edition of the Australian code for the care and use of animals for scientific purposes. Author Contributions SM-H, BM, PW, CT, SM, and ST conceptualized and designed the experiments. SM-H...
Source: Frontiers in Physiology - Category: Physiology Source Type: research