Genetics of Idiopathic Pulmonary Fibrosis.

Genetics of Idiopathic Pulmonary Fibrosis. Am J Med Sci. 2019 May;357(5):379-383 Authors: Barros A, Oldham J, Noth I Abstract Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease. IPF is a complex disease, with environmental and genetic factors variably contributing to disease susceptibility and outcomes. A host of common gene variants with modest effect size impart disease risk in patients with sporadic IPF, while rare variants with large effect size influence disease risk in those with familial interstitial pneumonia. In this review, we highlight several common and rare variants underpinning IPF risk and call attention to recently published studies informing our understanding of this risk. PMID: 31010464 [PubMed - in process]
Source: The American Journal of the Medical Sciences - Category: General Medicine Authors: Tags: Am J Med Sci Source Type: research