Probing the coding logic of thermosensation using spinal cord calcium imaging.
Probing the coding logic of thermosensation using spinal cord calcium imaging. Exp Neurol. 2019 Apr 20;: Authors: Ran C, Chen X Abstract The spinal cord dorsal horn is the first relay station of the neural network for processing somatosensory information. High-throughput recording methods facilitate the study of sensory coding in the cortex but have not been successfully applied to study spinal cord circuitry until recently. Here, we review the development of the in vivo two-photon spinal calcium imaging preparation and biological findings from the first systematic characterization of the spinal response to cutaneous thermal stimuli, focusing on the difference between the coding of heat and cold, and the contribution of different peripheral inputs to thermosensory response in the spinal cord. Here we also report that knockout of TRPV1 channel impairs sensation of warmth, and somatostatin- and calbindin2-expressing neurons in the spinal dorsal horn preferentially respond to heat. Future work combining this technology with genetic tools and animal models of chronic pain will further elucidate the role of each neuronal type in the spinal thermosensory coding and their plasticity under pathological condition. PMID: 31014574 [PubMed - as supplied by publisher]
In conclusion, miR-101 had neuropathic pain-attenuating activity through targeting mTOR.
Abstract Chronic nonspecific low back pain (CNLBP) is defined as pain or discomfort originating from the waist, which lasts for at least 12 weeks, but no radiculopathy or specific spinal diseases. CNLBP is a complicated medical problem and places a huge burden on healthcare systems. Clinical manifestation of CNLBP includes discogenic LBP, zygapophyseal joint pain, sacroiliac joint pain, and lumbar muscle strain. Further evaluation should be completed to confirm the diagnosis including auxiliary examination, functional assessment, and clinical assessment. The principle of the management is to relieve pain, restore ...
PMID: 31511783 [PubMed - in process]
ConclusionsThe present study showed that NSCLBP patients did not present higher fatigability or higher fatigability asymmetry in lumbar muscles than asymptomatic participants. The heterogeneity of the NSCLBP population, due to the absence of any specific etiology, may explain these findings.Graphic abstractThese slides can be retrieved under Electronic Supplementary Material.
Conclusion: The statistical analysis characterized chronic low back pain patients and identified factors contributing to a treatment response. Thus, this retrospective statistical algorithm represents an elegant method, which may contribute to future strategies toward a more individualized and improved mechanism based pain therapy.
ConclusionConsistent with research in middle and older adults, physical health conditions are associated with increased risk for the onset of suicidal thoughts and behaviors in adolescents. Mental health screening for adolescents with chronic medical conditions may help parents and physicians identify suicidality early.
Brucella is a facultative anaerobic Gram-negative bacillus. It resembles Mycobacterium tuberculosis and establishes infection intracellularly. Brucella infection shows a strong tissue preference for the reproductive system, bone, and fetal ectoderm (de Figueiredo et al., 2015). Early manifestations of brucellosis consist of fever, sweating, joint pain, symptoms of poisoning, chronic spine arthritis, testis or ovarian inflammation, and neurological complications. The prognosis of brucellosis tends to be poor and can result in disability if an early diagnosis was missed and/or no timely treatment was initiated.
Different types of pain can evolve toward a chronic condition characterized by hyperalgesia and allodynia, with an abnormal response to normal or even innocuous stimuli, respectively. A key role in endogenous analgesia is recognized to descending noradrenergic pathways that originate from the locus coeruleus and project to the dorsal horn of the spinal cord. Impairment of this system is associated with pain chronicization. More recently, activation of glial cells, in particular microglia, toward a pro-inflammatory state has also been implicated in the transition from acute to chronic pain. Both α2- and β2-adrene...
This study provides a basis for addressing the therapeutic relevance of oxytocin in chronic pain conditions. PMID: 31515587 [PubMed - as supplied by publisher]
Pain is one of the leading characteristics of injuries and nearly all diseases. Chronic pain presents a major health burden, and millions of individuals are suffering from various pains worldwide.1,8,14 According to the Medical Expenditure Panel Survey (MEPS) in 2008, in the United States, approximately 100 million adults were affected by chronic pain and the economic cost of pain was estimated to be between $560 and $635 billion annually.13 A large number of analgesics, including non-opioid analgesics (e.g., COX-2 inhibitors and other nonselective NSAIDs, acetaminophen, ketamine, and ketorolac) and opioid analgesics (e.g....