Nonnatural biosynthetic pathway for 2-hydroxylated xanthophylls with C50-carotenoid backbone

In this study, a carotenoid 2,2'-hydroxylase (crtG) from Brevundimonas sp. SD212 was coexpressed together with our laboratory-engineered C50-zeaxanthin and C50-astaxanthin biosynthetic pathways. We identified six novel nonnatural C50-xanthophylls, namely, C50-nostoxanthin, C50-caloxanthin, C50-adonixanthin, C50-4-ketonostoxanthin, C50-2-hydroxyastaxanthin, and C50-2,2′-dihydroxyastaxanthin.
Source: Journal of Bioscience and Bioengineering - Category: Biomedical Science Source Type: research