Title: EDCs and Estrogen Receptor Activity: A Pathway to Safer Chemical Design?
Julia R. Barrett, MS, ELS, a Madison, WI–based science writer and editor, is a member of the National Association of Science Writers and the Board of Editors in the Life Sciences.
About This Article open
Citation: Barrett JR. 2014. EDCs and estrogen receptor activity: a pathway to safer chemical design? Environ Health Perspect 122:A339; http://dx.doi.org/10.1289/ehp.122-A339
News Topics: Biochemistry, Endocrine Disruptors, Molecular Biology
Published: 1 December 2014
PDF Version (469 KB)
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Structural and Functional Profiling of Environmental Ligands for Estrogen Receptors
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Estrogen receptors are some of the primary targets of endocrine-disrupting chemicals (EDCs). In a new report in this issue of EHP, biochemical, structural, biophysical, and cell-based experiments reveal critical information about the activity of 12 EDCs at the molecular and atomic levels.1 The EDCs tested, including the plasticizer bisphenol A and the flame retardant tetrachlorobisphenol A, are suspected to have a role in the development of various cancers and developmental, reproductive, and metabolic disorders via interactions with estrogen receptors.
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Source: EHP Research - Category: Environmental Health Authors: Web Admin Tags: Featured News Science Selection Biochemistry December 2014 Endocrine Disruptors Molecular Biology Source Type: research
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