Virtual reality engages patients more than CT, booklets
Patients with an abdominal aortic aneurysm were more engaged and had a better...Read more on AuntMinnie.comRelated Reading: 4 practical applications of VR, AR in radiology SIR: Virtual reality beats fluoroscopy for catheter placement VR, AR elevate radiologists' value in future of medicine Virtual reality may help plan, guide glioma resection VR software may increase MRI segmentation efficiency
CONCLUSIONS: In aggregate, our results suggest that increased expression of miR-106a promotes VSMC cell apoptosis and down-regulates TIMP-2 through directly targeting its 3'-UTR, which in turn restores MMP production and ultimately accelerates ECM degradation. Therefore miR-106a is proposed to play a crucial role in AAA development and this will provide an update on the understanding of the clinical value of miRNAs as novel therapeutic targets for the treatment of this disease. PMID: 32767336 [PubMed - in process]
Publication date: Available online 13 August 2020Source: Acta Pharmaceutica Sinica BAuthor(s): Jinyang Li, Jiasheng Lu, Haiyan Guo, Jianfen Zhou, Songli Wang, Kuan Jiang, Zhilan Chai, Shengyu Yao, Xiaoyi Wang, Linwei Lu, Cao Xie, Yi Chen, Weiyue Lu
CONCLUSIONS These findings demonstrated that NORAD silencing suppressed proliferation, invasion, and migration and boosted apoptosis of glioma cells via downregulating the AKR1B1 expression, which may provide a potential therapeutic target for glioma treatment. PMID: 32778640 [PubMed - in process]
This study indicates that CD73 knockdown using a nanotechnological approach to perform nasal delivery of siRNA-CD73 to CNS can potentially regulate the glioblastoma immune microenvironment and delay tumor growth by inducing apoptosis.
Conclusion: GB/PNC is extremely rare tumors. Given its low prevalence, there are no studies that refer to the macroscopic characteristics of the tumor as well as evidence of the effectiveness of adjuvant treatment. Fluorescence-guided resection with 5-ALA is the surgical treatment of choice in surgery for high-grade gliomas; however, in GB/PNC, it may not be as useful since PNC may have less fluorescent marker uptake and be more dimly visualized when excited by light using the surgical microscope. PMID: 32754353 [PubMed]
Drug delivery is one of the major challenges in the treatment of central nervous system disorders. The brain needs to be protected from harmful agents, which are done by the capillary network, the so-called blood–brain barrier (BBB). This protective guard also prevents the delivery of therapeutic agents to the brain and limits the effectiveness of treatment. For this reason, various strategies have been explored by scientists for overcoming the BBB from disruption of the BBB to targeted delivery of nanoparticles (NPs) and cells and immunotherapy. In this review, different promising brain drug delivery strategies incl...
Publication date: September 2020Source: Journal of Clinical Neuroscience, Volume 79Author(s): Ryan P. Hamer, Swati Jain, Colin Teo, Will Ne-Hooi Loh, Hui-Minn Chan, Tseng T. Yeo, Kejia Teo
Publication date: Available online 7 August 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Weimin Yu, Li Xiao, Yumei Que, Siqi Li, Lili Chen, Pingping Hu, Rui Xiong, Francesca Seta, Hao Chen, Xiaoyong Tong
Publication date: Available online 11 August 2020Source: International Journal of Surgery Case ReportsAuthor(s): Ettore Dinoto, Felice Pecoraro, Arduino Farina, Alessia Viscardi, Guido Bajardi