The extent of ventilator-induced lung injury in mice partly depends on duration of mechanical ventilation.

Conclusions. Deleterious effects of MV are partly dependent on its duration. Even lower tidal volumes with PEEP may initiate aspects of VILI after 12 hours of MV. PMID: 23691294 [PubMed]
Source: Critical Care Research and Practice - Category: Intensive Care Tags: Crit Care Res Pract Source Type: research