Single Inhaler LABA/LAMA for COPD
Single Inhaler LABA/LAMA for COPD
Mario Malerba1,2*, Valentina Foci1,2, Filippo Patrucco1,2, Patrizia Pochetti1,2, Matteo Nardin3, Corrado Pelaia4 and Alessandro Radaeli5
1Respiratory Medicine, Department of Translational Medicine, University of Eastern Piedmont, Vercelli, Italy
2Respiratory Unit, Sant’Andrea Hospital, Vercelli, Italy
3Department of Medicine, Spedali Civili di Brescia, Brescia, Italy
4Department of Medical and Surgical Sciences, Section of Respiratory Diseases, University “Magna Græcia” of Catanzaro, Catanzaro, Italy
5Department of Emergency, Spedali Civili di Brescia, Brescia, Italy
Chronic obstructive pulmonary disease (COPD) is a common disabling disease characterized by progressive airflow obstruction. Great efforts were spent in the development of drugs able to improve symptoms, quality of life, reduce exacerbations, hospitalizations and the frequency of death of patients with COPD. The cornerstones of treatment are bronchodilator drugs of two different classes: beta agonists and muscarinic antagonists. Currently the Global initiative for COPD suggests the use of long acting beta agonists (LABAs) and long acting muscarinic antagonists (LAMAs) in combination for the majority of COPD patients, thus great interest is associated with the developing of LAMA/LABA fixed combination in the maintenance treatment of stable COPD. Many LAMA/LABA fixed dose combinations have been licensed in different countries and the clinical us...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Authors: Rombauts A, Abelenda-Alonso G, Cuervo G, Gudiol C, Carratalà J
Abstract
INTRODUCTION: Despite adequate antibiotic coverage, community-acquired pneumonia (CAP) remains a leading cause of hospitalization and mortality worldwide. It induces both a local pulmonary and a systemic inflammatory response, particularly significant in severe cases. The intensity of the dysregulated host response varies from patient to patient and has a negative impact on survival and other outcomes.
AREAS COVERED: This comprehensive review summarizes the pathophysiological aspects of the inflammatory response in CAP, brie...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Publication date: Available online 30 September 2020Source: Journal of Hazardous MaterialsAuthor(s): Anthony Beauvois, Delphine Vantelon, Jacques Jestin, Martine Bouhnik-Le Coz, Charlotte Catrouillet, Valérie Briois, Thomas Bizien, Mélanie Davranche
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
CONCLUSIONS: Xyloglucan/gelose plus ORS was effective and safe in treating acute diarrhea in children.
PMID: 33028102 [PubMed - as supplied by publisher]
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Source: European Journal of Sport Science - Category: Sports Medicine Authors: Brizuela, G. Sinz, S. Aranda, R. Mart ínez-Navarro, I. Source Type: research
Authors: Saavedra J, Reyes JG, Salinas DG
Abstract
Cytosolic Ca2+ concentration ([Ca2+ ]) has an important role in spermatozoa and hence it regulates fertilization. In male germinal cells, there are indirect evidences that this ion could regulate physiological processes in spermatogenesis. Since little is known about Ca 2+ homeostasis in spermatogenic cells, in this work we propose a mathematical model that accounts for experimental [Ca2+ ] dynamics triggered by blockade of the SERCA transport ATPase with thapsigargin in round rat spermatids, without external Ca2+ and with different extracellular lactate concentrat...
Source: Channels - Category: Molecular Biology Tags: Channels (Austin) Source Type: research
Conclusion Visual estimation had excellent intra-rater reliability in the assessment of neck active rotation and head tilt on infants with congenital muscular torticollis. Visual estimation had acceptable inter-rater reliability in the assessment of neck active rotation but not of head tilt. There was a wide variation in reliability with no correlation between reliability and clinical experience. Assessment tools for head tilt that are more psychometrically robust should be developed.What is Known:• A thorough assessment of infants presenting with torticollis is essential, using assessment tools with robust psychometr...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
Conclusion: By underlining the gaps of knowledge and attitude towards breastfeeding of nurses working in NICUs, this study provides an insight into what needs to be improved, with the aim of promoting higher rates of breastfeeding in the preterm population.What is Known:•Breastfeeding is particularly challenging in the preterm population, despite its universally recognized health benefits.•Improving healthcare professionals ’ knowledge and attitude towards breastfeeding has been shown to be crucial for promoting breastfeeding in NICUs.What is New:•Our results provide useful insight into nurses ’ ...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
Abstract
Trace metals concentrations of 25 elements were determined for 22 subcomponents of biodegradable and non-biodegradable waste samples representing the United States municipal solid waste (MSW) stream collected during three separate waste sorts. The subcomponent trace metal concentrations and estimated composition results were used to predict trace metal concentrations present in the overall MSW stream along with MSW compost and waste to energy (WTE) ash, which were compared to health-based standards (i.e., US EPA regional screening levels) and to values previously reported in the literature. These estimate...
Source: Chemosphere - Category: Chemistry Authors: Tucker EL, Chickering GW, Spreadbury CJ, Laux SJ, Townsend TG Tags: Chemosphere Source Type: research
Boosting the sensitivity of in vitroβ-lactam allergy diagnostic tests.
Chem Commun (Camb). 2020 Oct 14;56(80):11973-11976
Authors: Peña-Mendizabal E, Morais S, Maquieira Á
Abstract
The synthesis of structurally new haptens and the development of suitable antigens are essential for boosting the sensitivity of drug allergy diagnostic testing. Unprecedented structural antigens for benzylpenicillin and amoxicillin are characterised and evaluated in a cohort of 70 subjects with a turnkey solution based on consumer electronics.
PMID: 33033809 [PubMed - in process]
Source: Chemical Communications - Category: Chemistry Authors: Peña-Mendizabal E, Morais S, Maquieira Á Tags: Chem Commun (Camb) Source Type: research
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Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
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