Opposite Prognostic Impact of Single PTEN-loss and PIK3CA Mutations in Early High-risk Breast Cancer

Conclusion: In EBC, PTEN-loss is an independent predictor of poor outcome. When occurring singly, PTEN-loss and PIK3CA mutations have opposite prognostic impact. In HER2-positive disease, assessment of PTEN-loss by IHC appears unreliable and the marker is without clear prognostic significance.

Source: Cancer Genomics and Proteomics - April 23, 2019 Category: Cancer & Oncology Authors: LAZARIDIS, G., KOTOULA, V., VRETTOU, E., KOSTOPOULOS, I., MANOUSOU, K., PAPADOPOULOU, K., GIANNOULATOU, E., BOBOS, M., SOTIROPOULOU, M., PENTHEROUDAKIS, G., EFSTRATIOU, I., PAPOUDOU-BAI, A., PSYRRI, A., CHRISTODOULOU, C., GOGAS, H., KOUTRAS, A., TIMOTHEAD Tags: Article Source Type: research