Neoadjuvant Chemotherapy Alters Neuropilin-1, PlGF, and SNAI1 Expression Levels and Predicts Breast Cancer Patients Response

In this report, we are adding an extra finding, in which we show that the levels of circulating NRP-1 were significantly increased in patients who received NAC and had a partial response. Assessing patients who underwent NAC indicated that the levels of NRP-1 measured post-NAC were significantly higher in younger patients and patients with either a low or a medium body mass index (BMI), as well as in patients who remained with larger tumor size and partial response. Previously, we showed that SNAI1 expression in the immune cells collected from the peripheral blood of breast cancer patients was significantly higher in patients with stage I disease compared with higher stages (17). In this report, we found that SNAI1 expression in peripheral blood mononuclear cells (PBMCs) of patients who received NAC was significantly increased, especially in patients who showed a complete pathological response to the treatment, but did not increase in those who had a partial response, which indicates that SNAI1 might be a good candidate to be used as a predictive marker for a complete pathological response. In vitro experiments on breast cancer MDA-MB-231 cells was done to validate the clinical observations. The knockdown of NRP-1 in the cells sensitized them to the common chemotherapy regimen (Adriyamicin/cyclophosphamide + Taxane) used in the neoadjuvant setting, which can be translated in that, patients with low levels of NRP-1 might respond better to NAC and vice versa. Materials and Met...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Publication date: Available online 16 June 2019Source: Journal of Food Composition and AnalysisAuthor(s): Mª de Lourdes Samaniego-Vaesken, Teresa Partearroyo, Andrea Cano, Rafael Urrialde, Gregorio Varela-MoreirasAbstractAdded sugars encompass a number of ingredients used to improve flavour, texture and many characteristics from food products. Their increased intake from foods and beverages has been described by several studies and public health authorities recommend reducing their consumption. The use of low and no-calorie sweeteners (LNCS) has acquired a central role as partial or total substitutes for these controv...
Source: Journal of Food Composition and Analysis - Category: Food Science Source Type: research
U.S. News&World Report ’s newly released ranking of the nation's best children’s hospitals once again placed St. Louis Children’s Hospital in the top 50 in all 10 specialties it analyzes. The 13th annual ranking highlights the top hospitals in 10 pediatric specialties: cancer, cardiology and heart surgery, diabete s and endocrinology, gastroenterology and GI surgery, neonatology, nephrology, neurology and neurosurgery, orthopedics, pulmonology, and urology. St. Louis Children’s Hospital…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
Johns Hopkins Children's Center has been ranked as the best pediatric hospital in the state, and once again as one of the 10 best in the country, according to U.S. News&World Report. The annual Best Children’s Hospitals rankings are intended to help families of children with complex and rare conditions find the best medical care. The rankings highlight the top 50 hospital centers in 10 pediatric specialties: cancer, cardiology and heart surgery, diabetes and endocrinology, g astroenterology and…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
We report the application of RNA sequencing technology for high-throughput profiling of mRNA expression in breast cancer cell line
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Chaima Cherif ; Julien Vernerey ; Nadine Carbuccia ; Palma Rocchi ; Estelle DuprezSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMenin protein is encoded by the multiple endocrine neoplasia type 1 (MEN1) gene. It remains an enigmatic protein, known as a tumor suppressor but its roles in cancer development have attracted significant attention in recent years. The goals of this study is to understand how the Menin tumor suppressor can be oncogenic in Prostate, we have profiled Menin chromatin occupancy by chromatin immunoprecipitation coupled to high-throug...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Manish Aghi ; Jordan SpatzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCancer Fibroblasts Isolated from 2 GBM Cases.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Rebecca A Helmer ; Gurvinder Kaur ; Lisa A Smith ; Beverly S ChiltonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe helicase-like transcription factor (HLTF) gene – a tumor suppressor in human colorectal cancer (CRC) - is regulated by alternative splicing and promoter hypermethylation. The detection of hypermethylated HLTF DNA in fecal occult blood tests is an indicator of disease recurrence and poor survival. Hltf-deficiency in the ApcMin/+ mouse strain in creased the formation of intestinal adenocarcinoma with a high incidence of gross chromosomal instabilit...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Jing Li ; Wei Sun ; Wenge Zhu ; Wei ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOvarian cancer IGROV1 cells were studied to profile the expression of wild type (WT, Cisplatin Susceptible) cells and Cisplatin Resistant (CR) cells. The goal was to gain insights or to build hypotheses into the mechanisms of Cisplatin resistance in this cell-based model.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Grit Pattschull ; Susanne Walz ; Eva Ruehl ; Elmar Wolf ; Carsten P Ade ; Susanne Kneitz ; Andreas Rosenwald ; Bjoern von Eyss ; Stefan GaubatzSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusYAP/TAZ, downstream effectors of the Hippo pathway, are important regulators of proliferation. Here we show that the ability of YAP to activate mitotic gene expression is dependent on the Myb-MuvB (MMB) complex, a master regulator of genes expressed in the G2/M phase of the cell cycle. By carrying out ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Expression profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
T, Viñas I Abstract The risk posed by outbreaks associated with strawberries together with the safety issues of by-products from chlorine disinfection in the fruit industry has led to a search for alternative sanitizers. The disinfection capacity of peracetic acid (PA) at three concentrations (20, 40 and 80 ppm) and washing times (1 and 2 min) was compared to sodium hypochlorite (200 ppm) (NaClO) treatments and a water control, and its influence on the physico-chemical, biochemical and nutritional quality of strawberries was also studied. Counts on total aerobic mesophilic microorganisms were comparab...
Source: Food Microbiology - Category: Food Science Authors: Tags: Food Microbiol Source Type: research
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