Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated Multidrug Resistance in Cancer Cells
In conclusion, MET/SMO dual inhibitor Glesatinib antagonized P-gp mediated MDR by inhibiting its efflux functions. This work provided important information for further clinical trials.
Author Contributions
QC and Z-SC: conception and design. QC, C-YC, H-LG, NJ, SS, SA, and Z-SC: development of methodology. QC, C-YC, H-LG, PG, and NJ: acquisition of data. QC, C-YC, H-LG, NJ, and Z-SC: analysis and interpretation of data. QC, C-YC, LR, YY, D-HY, and Z-SC: writing, review, and/or revision of the manuscript. All authors read and approved the final manuscript.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Acknowledgments
We thank Dr. Stephen Aller for providing the human ABCB1 homology model. We thank Dr. Tanaji T. Talele for providing the computing resources for the docking study. We thank Drs. Susan E. Bates and Robert W. Robey (NCI, NIH, Bethesda, MD) for providing the cell lines. We thank the support of Guangzhou Postdoctoral Foundation of International Training for QC and NIH funding (No. 1R15GM116043-01) to Z-SC.
References
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Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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