Changes in Physical Fitness After 12 Weeks of Structured Concurrent Exercise Training, High Intensity Interval Training, or Whole-Body Electromyostimulation Training in Sedentary Middle-Aged Adults: A Randomized Controlled Trial

In conclusion, our results suggest that a 12-week structured exercise intervention improves physical fitness regardless of the training program in sedentary middle-aged adults. Despite slightly greater improvements in some physical fitness variables, the changes observed in the WB-EMS group were not superior to the other exercise programs. Introduction Cardiorespiratory fitness (VO2max) and muscular strength have been positioned as two independent powerful health markers (Amaro Gahete et al., 2017a). Epidemiological studies have indicated an inverse association of VO2max with coronary heart disease, cardiovascular disease events, different types of cancer, and all-cause mortality in both men and women of different ages, which is unaffected by different factors, such as alcohol or tobacco consumption (Kodama et al., 2009; Schmid and Leitzmann, 2015). Furthermore, it has reported that muscular strength is negatively associated with all-cause mortality even after controlling for physical activity levels and VO2max (Artero et al., 2012a; Volaklis et al., 2015; Liu et al., 2019). Several studies have shown that physical exercise is an effective strategy to fight against the high prevalence of chronic diseases (Pedersen and Saltin, 2015), improving physical fitness, and, consequently, increasing quality of life (Fitzgerald et al., 2004; Lee et al., 2010; Volaklis et al., 2015; Harber et al., 2017; Fletcher et al., 2018; García-Hermoso et al., 2018; Ozemek et al., 20...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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ConclusionsPA activates PXR signalling and suppresses NF-κB signalling, consequently causing ameliorating inflammation. Results highlight the importance of PXR–NF-κB crosstalk in colitis and suggest a novel therapeutic reagent.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
We describe a contiguous gene deletion of the ATM locus in a multi-generation family of Italian descent with a strong family history of pancreatic cancer. A deletion of one copy of the entire ATM gene was identified by routine panel testing and further characterized by chromosomal microarray analysis. An 11q22.3 microdeletion of approximately 960kb was identified that is predicted to result in loss of 10 genes including ATM. The deletion was identified in two additional family members including a presymptomatic daughter and an affected sibling. A normal disomic complement of the 11q22.3 region was detected in a third famil...
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
ConclusionsThis case series demonstrates that the use of a high frequency jet ventilator for cardiac MRI was feasible, safe, providing good quality cardiac imaging and avoiding anesthesia personnel to be inside the hazardous environment of MRI room. Future studies are needed to confirm its safety and efficiency in pediatric patients.ResumoJustificativa e objetivosA ressonância magnética (RM) cardíaca é uma técnica utilizada na avaliação de crianças com cardiopatias congênitas. A anestesia geral garante imobilidade, especialmente em pacientes não cooperador...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
ConclusionsThe trial demonstrated a favorable safety profile of the SQ HDM SLIT tablet in Japanese adult patients with AA. The treatment appeared to be efficacious in patients requiring rescue medication (ie, short-acting β2-agonist) at baseline in the efficacy assessment using asthma exacerbation during inhaled corticosteroid reduction (JapicCTI number 121847).
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 12 October 2019Source: Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)Author(s): Q. Xu, M. Lv, Y. Xia, Y. Zhao, W. Zhang, Y. ChenAbstractA 42-year-old woman presented with a ten-day history of dysphagia, slight chest pain and occasional vomiting. With the performance of thoracic and abdominal enhanced computed tomography (CT) and upper gastrointestinal contrast, once esophageal cancer was suspected. Significant activity mass in esophagus and mediastinal lymph nodes could be found on the imaging of 18F-FDG PET/CT, which also supported malignancy. However, T...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
CONCLUSIONS IQGAP3 may be a potential target gene for Kaempferol in the treatment of BC, and upregulation of IQGAP3 inhibits Kaempferol-induced apoptosis in BC cells by ERK1/2 signaling activation. Targeting IQGAP3 may contribute to the study of natural phytochemicals as anti-tumor drugs in BC. PMID: 31605603 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS PVT1 exerts an oncogenic role through activating Wnt/ß-catenin signaling in pituitary adenoma cells. The present results may provide a potential therapeutic target or approach for treating pituitary adenomas. PMID: 31604907 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS lncRNA TSLNC8 remarkably inhibited the proliferation and migration and accelerated apoptosis of lung cancer cells by targeting the IL-6/STAT3/HIF-1alpha signaling pathway. TSLNC8 may be a potential therapeutic target for the diagnosis and treatment of NSCLC. PMID: 31601776 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
John SamplesElizabeth Warren ’s presidential campaign has a new Facebook ad claiming Mark Zuckerberg, the CEO of Facebook, has endorsed Donald Trump for re-election. That claim is false, and Warren admits as much in the ad. Warren is not trying to mislead people about Zuckerberg. She is trying to control what can be said on Facebook. That is much more dangerous than any lie appearing in a campaign ad.Recently the Trump campaign ran an ad on Facebook saying former vice president Joe Biden had sought to fire a Ukrainian prosecutor investigating a company whose board included Biden ’s son. Many on the left like Wa...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
Publication date: Available online 12 October 2019Source: Materials Today: ProceedingsAuthor(s): A. Saikiran, M. Vivekanand, M. Prahalad, S. Yuvan, N. RameshbabuAbstractMicrowave synthesis of nanocrystalline Zn/Mg substituted and Zn/Mg-F co-substituted hydroxyapatites is reported in this study. Substitution of Zn/Mg is expected to increase the bioactivity, whereas the fluorine substitution is aimed for the attainment of chemical and thermal stability of the hydroxyapatite. The thermal stability of the nanopowders was studied by annealing the samples at 900 °C for 2 h. The phase composition and crystallite size of t...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
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