Network mapping of the conformational heterogeneity of SOD1 by deploying statistical cluster analysis of FTIR spectra.

This study provides a quantifiable picture of how conformational information at one particular site (for example, the copper-binding pocket) is related to the information at the second site (for example, the zinc-binding pocket), and how this relatedness is transferred to the global conformational information of the protein. The distance outputs were used to quantitatively generate a network capturing the folding sub-stages of SOD1.
PMID: 31011770 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - April 21, 2019 Category: Cytology Authors: Chowdhury S, Sen S, Banerjee A, Uversky VN, Maulik U, Chattopadhyay K Tags: Cell Mol Life Sci Source Type: research