Cryo-EM structure of the Ebola virus nucleoprotein – RNA complex

Ebola virus is an emerging virus that is capable of causing a deadly disease in humans. Replication, transcription and packaging of the viral genome are carried out by the viral nucleocapsid. The nucleocapsid is a complex of the viral nucleoprotein, RNA and several other viral proteins. The nucleoprotein forms large, RNA-bound, helical filaments and acts as a scaffold for additional viral proteins. The 3.1   Å resolution single-particle cryo-electron microscopy structure of the nucleoprotein – RNA helical filament presented here resembles previous structures determined at lower resolution, while providing improved molecular details of protein – protein and protein – RNA interactions. The higher resolution of the structure presented here will facilitate the design and characterization of novel and specific Ebola virus therapeutics targeting the nucleocapsid.
Source: Acta Crystallographica Section F - Category: Biochemistry Authors: Tags: Ebola virus nucleoprotein NP helix cryo-electron microscopy research communications Source Type: research

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