Cryo-EM structure of the Ebola virus nucleoprotein – RNA complex
Ebola virus is an emerging virus that is capable of causing a deadly disease in humans. Replication, transcription and packaging of the viral genome are carried out by the viral nucleocapsid. The nucleocapsid is a complex of the viral nucleoprotein, RNA and several other viral proteins. The nucleoprotein forms large, RNA-bound, helical filaments and acts as a scaffold for additional viral proteins. The 3.1 Å resolution single-particle cryo-electron microscopy structure of the nucleoprotein – RNA helical filament presented here resembles previous structures determined at lower resolution, while providing improved molecular details of protein – protein and protein – RNA interactions. The higher resolution of the structure presented here will facilitate the design and characterization of novel and specific Ebola virus therapeutics targeting the nucleocapsid.
By Polly Dunford, President and Chief Executive OfficerMarch 26, 2020Today, asCOVID-19 continues to invade our thoughts and lives, my mind is on frontline health workers.They don’t have the option to work from home, as many of us are doing today. They’re on the front lines as I write this—in hospitals, clinics, and triage centers around the world—putting themselves at risk to stop this pandemic. Now, more than ever,health workers need our support.Last week, as I began my new job as president&CEO at IntraHealth International, I saw that our country and global teams had mobilized immediately to ...
This viewpoint uses the absence of known effective treatment for Ebola virus disease to emphasise costs of off-label and compassionate drug use during an infectious disease outbreak.
What helps to contain an epidemic? A study of the Ebola crisis suggests that patients' trust in health workers can encourage patients to report illnesses and receive treatment.
Publication date: 24 March 2020Source: Cell Reports, Volume 30, Issue 12Author(s): Kai J. Rogers, Olena Shtanko, Rahul Vijay, Laura N. Mallinger, Chester J. Joyner, Mary R. Galinski, Noah S. Butler, Wendy Maury
[Thomson Reuters Foundation] Dakar -Community workers trained to help with Ebola response are being retrained to help with coronavirus
No new cases have been reported in the ongoing Ebola virus disease (EVD) outbreak in the Democratic Republic of the Congo since 17 February 2020 (Figure 1).
This article was originally published on March 25, 2020 by the Center for Global Development. The original post can be found here.
I decided to write this note because I am grieving. I am grieving for those infected and affected by the coronavirus pandemic, of course. But the deepest grief I feel right now is for my fellow healthcare workers who I know will be going through their toughest days in the next few months. I hate […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
The recent WHO decision to declare the novel coronavirus outbreak a Public Health Emergency of International Concern (PHEIC), while both appropriate and hardly surprising, offers the opportunity to reflect on the previous PHEIC which was declared, namely the Ebola epidemic in Kivu region, Democratic Republic of the Congo (DRC). And you should really say the ongoing Ebola epidemic, as during the time since the declaration in July 2019 through to the present day (March 2020), a total of 3,453 cases have been reported . The nCoV-2019 outbreak is still ballooning; as of today, over 400,000 confirmed cases worldwide with no ...
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