Prognostic and Predictive Value of Three DNA Methylation Signatures in Lung Adenocarcinoma

In conclusion, we built three DNA CpG signature-based models to identify LUAD lymph node metastasis by the CpG sites from primary tumor tissues, differentiate between tumor tissue and normal tissue, and predict the OS of LUAD patients, which highlight the relationship between clinical results (metastasis, survival) and methylation biomarkers in LUAD patients. The nomogram comprising LASSO Cox risk scores and clinicopathological factors may help predict the OS of LUAD patients and help individualized treatment of LUAD patients. Author Contributions XB and RS conceived and designed the experiments. XB and HD wrote the code (The Python code is available due to request). XB, YW, and SX wrote the paper. RS and KZ reviewed the manuscript. All authors read and approved the final manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We greatly thank Dr. Michael Rosemann and Prof. Dr. Michael J. Atkinson for helpful discussions and suggestions. We sincerely thank Sino-German (CSC-DAAD) Postdoc Scholarship Program for supporting the research of YW, and greatly thank the China Scholarship Council (CSC) for supporting the research and work of SX, RS, and XB. Supplementary Material The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fgene.2019.00...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research