Retrotransposon Elements among Initial Sites of Hepatitis B Virus Integration into Human Genome in the HepG2-NTCP Cell Infection Model

Hepatitis B virus (HBV) is one of the most common and deceitful human pathogens that causes liver injury ranging from an asymptomatic disease through acute and chronic hepatitis type B, to liver cirrhosis and primary hepatocellular carcinoma (HCC) [1]. HBV is recognized as the most potent viral oncogene responsible for thousands of liver cancer-related deaths annually [2]. Its oncogenic potency has been primarily aligned with integration of viral DNA into hepatocyte genome capable of compromising cell genome stability and modifying expression of individual genes [3].
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Tags: Original Article Source Type: research