Africa: As a Malian, the Slogan 'Zero Malaria Starts With Me' Has Special Meaning

[The Conversation Africa] For the millions worldwide living with the daily reality of malaria, bringing an end to this awful disease can feel like a distant dream.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news

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In this study, the 400 compounds in the Pathogen Box provided by the Medicines for Malaria Venture foundation were screened against Babesia bovis, Babesia bigemina, Babesia caballi, and Theileria equi. A fluorescence-based method using SYBR Green 1 stain was used for initial in vitro screening and determination of the half maximal inhibitory concentration (IC50). The initial in vitro screening performed using a 1 μM concentration as baseline revealed nine effective compounds against four tested parasites. Two “hit” compounds, namely MMV021057 and MMV675968, that showed IC50  100 were selected. The IC50s ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - Category: Parasitology Source Type: research
Researchers from the University of Oxford have published the Malaria Atlas, which shows how the numbers of children infected with a common malaria parasite have changed over 17 years.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Soft Matter, 2019, Accepted Manuscript DOI: 10.1039/C9SM00677J, PaperAnil Kumar Dasanna, Dmitry A. Fedosov, Gerhard Gompper, Ulrich Sebastian Schwarz Red blood cells in shear flow show a variety of different shapes due to the complex interplay between hydrodynamics and membrane elasticity. Malaria-infected red blood cells become generally adhesive and... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - Category: Chemistry Authors: Source Type: research
Publication date: September 2019Source: Biomedicine &Pharmacotherapy, Volume 117Author(s): Qingjun Pan, Zejian Liu, Shuzhen Liao, Lin Ye, Xing Lu, Xiaoqun Chen, Zhihang Li, Xinxin Li, Yong-Zhi Xu, Huafeng LiuAbstractSystemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by inflammation and abnormal production of autoantibody, but the mechanisms of the aberrant immune responses are currently unknown. Recently, growing evidence has suggested that infection plays a pivotal role in SLE. Here, we investigate the role of infectious agents (e.g., Epstein-Barr virus, parvovirus B19, human T-lymphotro...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
[Ghanaian Times] Waste management expert Zoomlion and a member of the Jospong Group of Companies in collaboration with the Government of Ghana through the Ministry of Health, Ghana Health Services and the Noguchi Memorial Centre have began an extensive training of key malaria control players across the country towards the implementation of a national malaria control programme, which focuses mainly on killing the larvae of mosquitos.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
(Institute for Health Metrics and Evaluation) New high-resolution maps show the global burden of Plasmodium falciparum and Plasmodium vivax, the two parasites that cause the majority of malaria cases worldwide.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
The challenge in anti-malarial chemotherapy is based on the emergence of resistance to drugs and the search for medicines against all stages of the life cycle of Plasmodium spp. as a therapeutic target. Nowadays,...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Annually, many pregnancies occur in areas of Plasmodium spp. transmission, particularly in underdeveloped countries with widespread poverty. Estimations have suggested that several million women are at risk of developing malaria during pregnancy. In particular cases, systemic infection caused by Plasmodium spp. may extend to the placenta, dysregulating local homeostasis and promoting the onset of placental malaria; these processes are often associated with increased maternal and fetal mortality, intrauterine growth restriction, preterm delivery, and reduced birth weight. The endeavor to understand and characterize the mech...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Most vaccines for diseases in low- and middle-income countries fail to be developed because of weak or absent market incentives. Conquering diseases such as tuberculosis, HIV, malaria, and Ebola, as well as illnesses caused by multidrug-resistant pathogens, requires considerable investment and a new sustainable model of vaccine development involving close collaborations between public and private sectors.
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Perspectives Source Type: research
Planta Med DOI: 10.1055/a-0952-3677Malaria treatment and control have become increasingly difficult because of the spread of drug-resistant strains of Plasmodium falciparum and Plasmodium vivax. Thus, there is a continuous need to develop new combination therapies such as artemisinin-based combination therapies (ACTs) to contrast the emergence of resistant Plasmodium strains. Despite ACT has been recommended by the World Health Organization since 2001, its overall deployment in poor endemic areas is very slow, principally due to its high cost. In the malaria endemic areas, plant remedies are still widely used mostly withou...
Source: Planta Medica - Category: Drugs & Pharmacology Authors: Tags: Original Papers Source Type: research
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