The Analysis of Key Factors Related to ADCs Structural Design

Conclusion and Perspective With in-depth understandings of antibodies, linkers, and payloads, ADCs have also achieved great development. The linkage strategy and target diversity have already improved the delivery of the payloads to tumor tissues and reduced exposure to normal tissues. With the development of payloads, some novel potent payloads are used by ADCs, which allows researchers to exploit novel linkers to attach the antibody and payloads without disturbing their potency (Dragovich et al., 2018). Furthermore, some irrelevant antigen-target ADCs also may exert toxicity to tumor cells due to the vascular gap of tumors relative to the normal tissues, which is big enough to make ADCs penetrate into tumor cells (Cardillo et al., 2011), indicating the specific recognition of ADCs by tumor tissues on another aspect. Some prodrug strategies also are used in ADCs design, which modified the toxic payloads to inactive prodrugs, then utilized self-immolation groups and took advantage of the intratumoral environment to reduce the prodrugs to prototype drugs to exert intrinsic activity (Pei et al., 2018). Moreover, nanoparticles combining with the strategy of ACD prodrugs could also increase the activity and circumvent MDR (Qi et al., 2017). The key issues of ADCs are optimization of the appropriate antibody, the choice of proper antigen, the selection of high-activity cytotoxic payloads, stable linkage technology and optimization of DAR in future development. These strategies w...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

Related Links:

What impact do antibiotic-related changes of the gut microbiome have on efficacy of immune-checkpoint inhibitors?Annals of Oncology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
'Chinese restaurant syndrome' was coined in the 1960s and refers to headaches, nausea and sweating after eating Chinese food. Campaigners say it's a 'xenophobic myth'.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
For patients with life-altering illnesses or anyone just getting older, it helps to roll with the punches and make the best of the here and now.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Cancer Elderly Books and Literature Medicine and Health Source Type: news
Observing how Chinese 2- and 3-year-olds navigated a second language, I wondered whether I could have done this for my children.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Children and Childhood Bilingual Education China Language and Languages Day Care Centers English Language Source Type: news
Men with early stage prostate cancer did not show benefits from a vegetable-rich diet.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Prostate Gland Prostate Cancer Vegetables Diet and Nutrition Prostate Specific Antigen Source Type: news
Bundled up in winter clothes as they head home for the Lunar New Year holiday amid a health scare over a mystery new virus, Chinese travelers on the teeming concourse of Beijing West station were evenly split between the masked and the barefaced.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
China has reported a sharp rise in the number of people infected with a new coronavirus, including the first cases in the capital
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
An outbreak of a new coronavirus in China has spread to more cities, Chinese authorities said on Monday, as the number of patients tripled and a third person died, stoking concerns about containment of the illness.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Chinese authorities and the World Health Organization (WHO) say a new strain of coronavirus is behind the outbreak of pneumonia in the central city of Wuhan, which has erupted just ahead of the Lunar New Year, the country's biggest festival.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
The number of cases of the respiratory illness triples, as patients reported in Beijing and Shenzhen.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
More News: Academia | Acute Leukemia | Acute Myeloid Leukemia | Allergy & Immunology | Biology | Biotechnology | Breast Cancer | Breast Carcinoma | Cancer | Cancer & Oncology | Cancer Therapy | Carcinoma | Chemistry | Chemotherapy | China Health | Clinical Trials | Diphtheria | Drugs & Pharmacology | Environmental Health | Epithelial Cancer | Fruit | Grants | Hematology | Hepatocellular Carcinoma | HER2 | Herceptin | Laboratory Medicine | Leukemia | Liver | Liver Cancer | Lymphoma | Melanoma | Men | Molecular Biology | Multidrug Resistance | Nanotechnology | Orthopaedics | Ovarian Cancer | Ovaries | Pharmaceuticals | Polyethylene Glycol | Reproduction Medicine | Science | Skin Cancer | Slovakia Health | Statistics | Study | Toxicology | Urology & Nephrology | USA Health