Ultrasound for Breast Cancer Screening in High-Risk Women: Results From a Population-Based Cancer Screening Program in China

Conclusions: We found the diagnostic yield of ultrasound screening for breast cancer in high-risk population was satisfactory. Prediction models based on environmental risk factors had limited prediction accuracy and need to be improved in the future. Introduction With an estimate of 2,088,849 newly diagnosed cases in 2018 worldwide, breast cancer is the most frequently diagnosed cancer for women and is also the leading cause of cancer-related deaths (1). In China, the burden of breast cancer increased dramatically for the past decades, with incidence and mortality of 28.77 per 10,000 and 6.35 per 10,000, respectively in 2014 (2). While advantages in treatment have improved the overall outcomes of breast cancer, evidences from observational studies and randomized controlled trials have clearly demonstrated the effectiveness of breast cancer screening in reducing the mortality of breast cancer (3–5). In most cancer screening programs, mammography was regarded as main screening method. However, the diagnostic accuracy of mammography for breast cancer was not equal in all women. The overall sensitivity of mammography for detecting breast cancer was around 85%, but it dropped dramatically to 47.8–64.4% for women with dense breast tissue (6). Previous studies have demonstrated that women with dense breast had an elevated risk of breast cancer (7). Therefore, such limitation of mammography may limit the its screening efficacy in population having a high proport...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

Related Links:

In this study, we evaluated the changes in BMD according to adjuvant treatment in premenopausal women with breast cancer.MethodsBetween 2006 and 2010, BMD data of 910 premenopausal women with breast cancer before operation and 1, 2, 3.5, and 5  years post-operation were retrospectively analyzed. The patients were divided according to the type of treatment: observation (O), tamoxifen (T), chemotherapy (C), C followed by T (C → T), and gonadotropin-releasing hormone (GnRH) agonist with T (G + T).ResultsAfter 5  years of follow-up, BMD changes were similar between the T and O groups ...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionsIn contrast to prior reports, older breast cancer survivors were not more likely to experience recurrent falls than age-matched counterparts. These findings underscore the need for incorporation of cancer-free control populations in survivorship studies to distinguish cancer sequelae from processes related to aging.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Obesity is characterized by an excess of adipose tissue, due to adipocyte hypertrophy and hyperplasia. Adipose tissue is an endocrine organ producing many bioactive molecules, called adipokines. During obesity, dysfunctional adipocytes alter adipokine secretion, contributing to pathophysiology of obesity-associated diseases, including metabolic syndrome, type 2-diabetes, cardiovascular diseases and many types of malignancies. Circulating adiponectin levels are inversely correlated with BMI, thus adiponectin concentrations are lower in obese than normal-weight subjects. Many clinical investigations highlight that low adipon...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
In this study among young br...
Source: Health and Quality of Life Outcomes - Category: International Medicine & Public Health Authors: Tags: Research Source Type: research
Authors: Knight C, Logan V, Fenlon D Abstract Women who have been treated for breast cancer may experience vulvo-vaginal atrophy (VVA)/genitourinary syndrome of menopause (GSM). This is a progressive condition and will not improve without treatment. Whilst vaginal oestrogen is the most effective treatment for GSM, many breast cancer survivors and clinicians remain reluctant to use it. Laser therapy is emerging as an alternative treatment for this condition but there is little evidence available as to its value in this setting. We undertook a systematic literature review to identify available evidence for the use of...
Source: Ecancermedicalscience - Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research
AbstractExperimental and epidemiologic studies suggest that light at night (LAN) exposure disrupts circadian rhythm, and this disruption may increase breast cancer risk. We investigated the potential association between residential outdoor LAN and breast cancer risk. A population-based case –control study was conducted in Vancouver, British Columbia and Kingston, Ontario, Canada with incident breast cancer cases, and controls frequency matched by age in the same region. This analysis was restricted to 844 cases and 905 controls who provided lifetime residential histories. Using time- weighted average duration at each...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research
This study investigated how a history of menopausal hormone therapy (MHT) impacts clinical outcomes overall and in different subgroups of breast cancer patients. The study included 814 primary breast cancer patients aged ≥50 years in Sweden (2002–2012) with follow-up until 2016. Associations between patient- and tumor characteristics, recurrences, and overall survival were analyzed in relation to MHT. After a median follow-up of 7 years, 119 recurrences, and 111 deaths occurred. Ever MHT (n = 433, 53.2%) was associated with a lower BMI, frequency of alcohol abstinence, and histological grade, higher frequency of o...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Abstract Objective To identify the biomarkers of response to neoadjuvant chemotherapy in early luminal breast cancer. Methods A cross-sectional study that included all patients with early or locallyadvanced luminal breast cancer submitted to neoadjuvant chemotherapy between 2013 and 2014. Demographic, clinic and pathologic data were retrieved from patient records. The expressions of the estrogen receptor (ER), the progesterone receptor (PR), and Ki67 were analyzed by immunohistochemistry (IHC). The status of the human epidermal growth factor receptor 2 (HER2) was evaluated by IHC and fluorescent in situ hybridization (FISH...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
In conclusion, this study suggests that epigenetic age acceleration is significantly associated with lung function in women older than 50 years. We hypothesised that this could be due to menopause. However, we have observed that menopause has minimal effect and therefore there is possibility of other unknown physiological factors at older age in females mediating the epigenetic age acceleration effect on lung function. While, it is still unknown what exactly epigenetic aging from DNA methylation measures, this study suggests it can be utilised as one of the important factors to assess women's lung health in old age. DNA me...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study investigates weight trajectories in early BC patients at 2  years post-primary treatment, examining potential contributing factors such as age, race, and receipt of chemotherapy, anti-HER-2 therapy, and endocrine treatment (ET).MethodsA single institution cohort of newly diagnosed women age 21 and older with early breast cancer patients (Stage 0 –3) were identified by retrospective chart review (diagnosis year 1995 to 2016). Log-binomial regression models for net weight changes at 2 years post-primary treatment including patient demographic, clinical, and treatment characteristics.ResultsThe fina...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
More News: Academia | Academies | Breast Cancer | Breastfed | Cancer | Cancer & Oncology | Cardiovascular & Thoracic Surgery | China Health | Education | Endoscopy | Environmental Health | Epidemiology | Ghana Health | Harvard | India Health | Lower Endoscopy | Malaysia Health | Mammography | Medical Ethics | Men | Menopause | Middle East Health | Netherlands Health | Nutrition | Oman Health | PET Scan | Radiology | Reproduction Medicine | Rural Health | Science | Statistics | Study | Training | Ultrasound | Universities | Universities & Medical Training | USA Health | Women