CD4+ T-Cells With High Common γ Chain Expression and Disturbed Cytokine Production Are Enriched in Children With Type-1 Diabetes

This study was carried out in accordance with the recommendations of the Ethical Committee of the Medical Faculty of the Heinrich-Heine-University Duesseldorf, Germany (ID 4844) with written informed consent from all subjects. All subjects (older than 14 years) and their legal guardians gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Ethical Committee of the Medical Faculty of the Heinrich-Heine-University Duesseldorf, Germany. Author Contributions JS designed the study, performed experiments, analyzed and interpreted data, and wrote the manuscript. NM performed experiments, analyzed data, reviewed, and edited the manuscript. JAC, SK, and CR recruited patients and revised the manuscript. TM and EM contributed to the conceptualization and reviewed/edited the manuscript. MJ designed the study, analyzed and interpreted data, and wrote the manuscript. All of the contributing authors approved the final version of the manuscript. JS is the guarantor of this work, and as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Funding This work was supported in part by a grant from the German Federal Ministry of Education and Research (BMBF) to the DZD (Pediatric diabetes biomaterial bank 2.0, grant number 82DZD01802). This study was supported in part by a grant from the Elternitiative Kinderkrebsklinik e.V. to JS. Conflict of In...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research