Stage of Gestation at Porcine Epidemic Diarrhea Virus Infection of Pregnant Swine Impacts Maternal Immunity and Lactogenic Immune Protection of Neonatal Suckling Piglets

In this study, we infected pregnant first parity gilts in their first, second and third trimesters of gestation with PEDV to determine the impact of stage of gestation on generation of maternal B-cell immunity, the gut-MG-sIgA axis and lactogenic immune protection in PEDV challenged piglets. Our goal was to identify innate and adaptive immune factors during pregnancy that influence lymphocyte trafficking, in addition to immune correlates of lactogenic immune protection in neonatal suckling piglets. Understanding the impact of stage of gestation at PEDV infection or exposure on maternal immunity will allow more precise maternal vaccination protocols to target the time when the animal is most immunologically responsive. Optimizing vaccine efficacy for gestating and lactating animals will enhance lactogenic immunity in neonates and decrease morbidity and mortality associated with neonatal enteric disease. Results Overall Summary of Results and Significance for the Major Immune and PEDV Protection Parameters Assessed An overall summary of the statistically significant results (Table 1) illustrates that PEDV infection of gilts at different stages of gestation (Figure 1) affects multiple maternal systemic immune parameters prepartum, including natural killer (NK) cells, cytokines, B cells, and PEDV Abs and antibody secreting cells (ASCs). In addition, significant postpartum effects on lactogenic immune parameters in colostrum and milk were observed including significantly increa...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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PTSD among healthcare providers is an important issue. How prevalent is this condition among emergency physicians practicing in the United States?Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Emergency Medicine Journal Article Source Type: news
CHARLESTON, S.C. - A charity and a water supplier on Oct. 4 moved in South Carolina federal court for permission to amend their complaint against the United States related to groundwater contamination from aqueous film forming foam (AFFF) to add claims against new parties including the 3M Co., Tyco Fire Products LP and others (Security Water District, et al. v. United States of America [In re: Aqueous Film Forming Foam], No. 19-2187, MDL 18-2873, D. S.C.).
Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News - Category: Medical Law Source Type: news
More than 60 percent of CBD users were taking it for anxiety, according to a survey of 5,000 people. Does it help?
Source: NYT Health - Category: Consumer Health News Authors: Tags: Cannabis Foods and Products Anxiety and Stress Marijuana Mental Health and Disorders Drugs (Pharmaceuticals) Post-Traumatic Stress Disorder Sleep Addiction (Psychology) Research Clinical Trials Insomnia Depression (Mental) Hemp Source Type: news
This paper describes the implementation of an influenza vaccine screening and administration process to improve influenza vaccination rates among pediatric hematology and oncology inpatients.Pediatric Nursing
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pediatrics Journal Article Source Type: news
ConclusionThe ease of mobilization, superior blood supply and minimal donor site morbidity make it an ideal flap and a reliable alternative when other techniques fail.
Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
Discussion Female-to-male transgender patients often undergo chest contouring as their initial gender affirmation surgery. As the surgical treatment of gender dysphoria continues to grow, it is imperative for plastic surgeons to understand the surgical options and associated outcomes for transmasculine top surgery. Future research is needed to improve patient selection, surgical decision making, and patient-reported outcomes for different chest contouring techniques. In addition, there is a significant knowledge gap for the ideal nipple-areolar complex shape, size, and location.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Review Paper Source Type: research
l;nke G Abstract Mononuclear phagocytes, including monocytes and macrophages, are a central component of the host's innate immune system designated to protect against invading pathogens. However, these cells do not only interact with various parts of the innate and adaptive immune system, but also fulfill indispensable duties during the control of tissue homeostasis and organ function. Moreover, macrophages are crucially involved in tissue remodeling and repair in response to damage. Simultaneously, mononuclear phagocytes might also contribute to the pathogenesis of various inflammatory and autoimmune diseases. In...
Source: Advances in Immunology - Category: Allergy & Immunology Authors: Tags: Adv Immunol Source Type: research
Abstract Neutralizing antibodies against human immunodeficiency virus subtype 1 (HIV-1) bind to its envelope glycoprotein (Env). Half of the molecular mass of Env is carbohydrate making it one of the most heavily glycosylated proteins known in nature. HIV-1 Env glycans are derived from the host and present a formidable challenge for host anti-glycan antibody induction. Anti-glycan antibody induction is challenging because anti-HIV-1 glycan antibodies should recognize Env antigen while not acquiring autoreactivity. Thus, the glycan network on HIV-1 Env is referred to as the glycan shield. Despite the challenges pre...
Source: Advances in Immunology - Category: Allergy & Immunology Authors: Tags: Adv Immunol Source Type: research
The authors regret that there is a type error in the introduction section, the mid-nineteenth century needs to be, replaced with mid twentieth century.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: Corrigendum Source Type: research
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