Transiently Activated Human Regulatory T Cells Upregulate BCL-XL Expression and Acquire a Functional Advantage in vivo

This study was carried out in accordance with the Helsinki Declaration and approved by the Oxfordshire Research Ethics Committee B (approval number 07/H0605/130) with written informed consent from all subjects. The animal studies were carried out in strict accordance to the recommendations of the UK Animals (Scientific Procedures) Act of 1986. The protocol was approved by the University of Oxford Animal Care and Ethics Review committee and all procedures were carried under PPL P8869535A. Author Contributions JH, FI, KM, RG, and GB performed the experiments. JH, FI, KM, and KW conceived and designed the experiments. JH and FI analyzed the data. JH, FI, and KW wrote the paper. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments This work was supported by grants from the Kidney Research UK (SF1/2014), the British Heart Foundation (FS/12/72/29754), intramural Medical Research Fund pump priming fund (to JH and FI) and the European Union FP7 Integrated Project: BIO-DrIM (305147). JH is Kidney Research UK Senior Fellow and a recipient of ESOT Junior Basic Science Research grant, FI is a Wellcome Trust CRCD Fellow. The sponsors had no role in gathering, analyzing or interpreting the data. The authors would like to thank the staff of the plastic surgery theaters at the John Radcliffe Hospital and Mr T. Goodacre f...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research