Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions

In conclusion, we show that protein-bound MG-H1 is increased in MS lesions compared to white matter of NDCs and is present in activated GFAP+ astrocytes. This indicates that MGO-derived AGEs formed in glycolytic astrocytes may activate RAGE-positive microglia/macrophages in MS lesions and contribute to the inflammatory microenvironment. Further research is needed to elucidate whether lowering MG-H1 production in MS lesions is a therapeutic option for MS. Author Contributions SW performed the experiments, analyzed the data, and wrote the manuscript. TV supervised the experiments and wrote the manuscript. JS designed methods and performed measurements. JvH supervised immunohistochemistry, analyzed data, and revised the manuscript. SA provided CSF samples and revised the manuscript. VS research design and biobank sample collection. CS supervised the experiments and revised the manuscript. JH supervised the experiments and revised the manuscript. KW supervised the experiments and wrote the manuscript. Funding The Special Research Fund UHasselt (12N31BOF). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We would like to thank Marleen van Greevenbroek for her advice regarding the statistical analysis and Marjo van de Waarenburg and Bieke Broux for technical assistance. Supplementary Material The Sup...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research