Histopathological examination of an embolus in infective endocarditis: Case report and review of the literature

Publication date: Available online 23 April 2019Source: Interdisciplinary NeurosurgeryAuthor(s): Kyle P. O'Connor, Gina S. Perez, Bappaditya Ray, Jo Elle G. Peterson, Bradley N. BohnstedtAbstractA 62-year-old woman with history of chronic back pain and vertebral osteomyelitis presented with right hemiparesis and aphasia with last known well 10 h prior to presentation and a CT angiography demonstrating a left M1 occlusion. A thrombectomy was performed with resultant TICI-2b improving NIHSS from 28 pre-thrombectomy to 19 post-thrombectomy. Pathologic examination of the embolus demonstrated abundant bacterial colonies. While echocardiography was negative for valvular vegetations, fluoroscopy demonstrated abnormal mechanical valve motion. Blood cultures grew Enterococcus faecalis for which antibiotics were initiated. NIHSS continued to improve to a score of 12. There are rare cases in the literature that discuss diagnosis and initiation of antibiotics assisted by histopathologic examination of the embolus. Routine histopathologic evaluation of emboli may facilitate timely diagnosis and early antibiotic initiation in the setting of septic emboli.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research

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This study compares the effect of Helicobacter (H.) pylori and Lactobacillus (L.) acidophilus on the cytokine profile of PBMCs of 5 men with abdominal aortic aneurysm (AAA) and 5 men with normal/insignificant angiography, CT-Scan and ultrasonography results in the single-culture and in the co-culture with HUVECs. IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-13, IL-17A, IL-17 F, IL-21, IL-22, IFN-γ and TNF-α were measured in culture supernatants using a commercial fluorescent-labeled-bead assay.In general, CagA+ H. pylori-extract induced higher production of IFN-γ, IL-13 and IL-21 by PBMCs. Treatment of ...
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
We report a case of a young male with no prior genitourinary history who presents to an emergency department with sudden onset gross hematuria, clot retention, and right-sided flank pain. On evaluation, he was found to have a renal artery aneurysm bleeding into his collecting system and underwent renal artery embolization and rapid resolution of his hematuria. Renal vascular pathology should be considered in the differential diagnosis and timely diagnosis of this condition is imperative as surgical interventions have proven to be life-saving. PMID: 32065873 [PubMed - in process]
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
CONCLUSIONS: BTX-A treatment using either a trigone-sparing or trigone-including injection template resulted in significant, but not location-dependent, improvement in IC/BPS symptom scores at 30 and 90 day points post-procedure with no significant difference in post-treatment complication profiles. PMID: 32065870 [PubMed - in process]
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
Authors: Mann M, Calio BP, Mark JR, Chelluri R, Hufnagel E, Reese A, Lallas CD, Trabulsi EJ, Chandrasekar T, Shenot PJ, Halpern E, Gomella LG Abstract INTRODUCTION: To assess whether standard American Urological Association (AUA) and other recommendations for prostate biopsy prophylaxis provide sufficient coverage of common urinary organisms responsible for post biopsy infections by comparing local antibiograms in Philadelphia-area hospitals. MATERIALS AND METHODS: De-identified culture results derived from antibiograms were collected from six academic and community hospitals in the Philadelphia region. Analysi...
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
CONCLUSION: Large variability exists in the definitions, methods of reporting, and analysis of PD-associated peritonitis across trials and observational studies. Standardizing definitions for reporting of peritonitis and associated outcomes will better enable assessment of the comparative effect of interventions on peritonitis. This will facilitate continuous quality improvement measures through reliable benchmarking of this patient-important outcome across centers and countries. PMID: 32063197 [PubMed - as supplied by publisher]
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
CONCLUSIONS: Insertion-related complications leading to significant adverse events following laparoscopic placement of PD catheters are common. Many complications occur before the start of PD. Insertion-related complications are an important area of focus for future research and quality improvement efforts. PMID: 32063191 [PubMed - as supplied by publisher]
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
ConclusionsCardiac rehabilitation programs containing exercise may provide broader cardiovascular benefits compared to those without exercise.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 18 February 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): Alexandre Lannou, Cédric Carrié, Sébastien Rubin, Hugues De Courson, Matthieu Biais
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
Publication date: Available online 18 February 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): Mathieu Tourangeau, Issam Tanoubi, Roger Perron, Marie-Ève Bélanger, Komi Sodoké, Pierre Drolet, Arnaud Robitaille, Mihai Georgescu
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
In this study, 91 adolescents (10-24 years; 78 females) including 30 chronic pain patients with high pain-related distress, 29 chronic pain patients with low pain-related distress, and 32 healthy peers without chronic pain completed a developmentally appropriate T–S learning paradigm. We measured self-reported fear, psychophysiology (skin conductance response), and functional magnetic resonance imaging responses (N = 72 after functional magnetic resonance imaging exclusions). After controlling for age and anxiety symptoms, patients with high pain-related distress showed altered self-reported fear and frontolimbic act...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
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