Effect of Quercetin Rich Onion Extracts on Bacterial Quorum Sensing

This study aimed to evaluate the antimicrobial and anti-QS potential of organic extracts of onion varieties and its representative phenolic compounds quercetin aglycone and quercetin 3-β-D-glucoside in the QS model bacteria Chromobacterium violaceum ATCC 12472, Pseudomonas aeruginosa PAO1, and Serratia marcescens MG1. Three phenolic extracts were obtained: red onion extract in methanol acidified with 2.5% acetic acid (RO-1), white onion extract in methanol (WO-1) and white onion extract in methanol ammonium (WO-2). Quercetin 4-O-glucoside and quercetin 3,4-O-diglucoside were identified as the predominant compounds in both onion varieties using HPLC-DAD and LC-ESI-MS/MS. However, quercetin aglycone, cyanidin 3-O-glucoside and quercetin glycoside were identified only in RO-1. The three extracts showed minimum inhibitory concentration (MIC) values equal to or above 125 μg/ml of dried extract. Violacein production was significantly reduced by RO-1 and quercetin aglycone, but not by quercetin 3-β-D-glucoside. Motility in P. aeruginosa PAO1 was inhibited by RO-1, while WO-2 inhibited S. marcescens MG1 motility only in high concentration. Quercetin aglycone and quercetin 3-β-D-glucoside were effective at inhibiting motility in P. aeruginosa PAO1 and S. marcescens MG1. Surprisingly, biofilm formation was not affected by any extracts or the quercetins tested at sub-MIC concentrations. In silico studies suggested a better interaction and placement of quercetin aglycon...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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ConclusionThe study revealed that professional nurses need effective support, mentoring and supervision throughout IMCI implementation by the Mother, Child and Women Health (MCWH) coordinators. Caregivers and mothers need to know the importance of providing a comprehensive child history to professional nurses and therefore they need to be encouraged to disclose all relevant information during the IMCI process.
Source: International Journal of Africa Nursing Sciences - Category: African Health Source Type: research
Phys. Chem. Chem. Phys., 2019, Accepted Manuscript DOI: 10.1039/C9CP02585E, PaperQiuShi Song, Zheng Zhang, Hongwei Xie, Huayi Yin, ZhiQiang Ning Carbonization of Nb has been systemically investigated in Ar atmosphere and molten salt. The carbonization of transitional metals was considered from thermodynamics and kinetics. Dynamic barriers for the formation of... The content of this RSS Feed (c) The Royal Society of Chemistry
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Dalton Trans., 2019, Accepted Manuscript DOI: 10.1039/C9DT02472G, PaperLu Zhai, Jing −Wei Yu, Jin Zhang, Wen-Wei Zhang, lifeng Wang, Xiaoming Ren A multifunctional material, with two or more types of functionalities in a single material, might give new phenomena and novel applications. Metal −organic frameworks (MOFs) or porous coordination polymers (PCPs) can... The content of this RSS Feed (c) The Royal Society of Chemistry
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CrystEngComm, 2019, Accepted Manuscript DOI: 10.1039/C9CE00969H, PaperZiqian Zhu, Yufang Tao, Yansong Jiang, Liying Zhang, Jianing Xu, Li Wang, Yong Fan Two scandium coordination polymers (Sc-CPs), [Sc(L1)2(DMF)] (DMF = N,N ’- dimethyl formamide, H2L1 = pyrazine-2,3-dicarboxylic acid) (1) and [Sc(L2)(C2O4)0.5(H2O)2]•H2O (H2L2 = pyrazine-2,5-dicarboxylic acid) (2) were prepared via hydrothermal and microwave heating... The content of this RSS Feed (c) The Royal Society of Chemistry
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CrystEngComm, 2019, Accepted Manuscript DOI: 10.1039/C9CE00661C, PaperXia-Lin Dai, Alexander P. Voronin, Wei Gao, German L. Perlovich, Tong-Bu Lu, Jia-Mei Chen 5-Fluorouracil (5FU) is a BCS class III drug with good aqueous solubility and poor permeability, which severely limits its transdermal permeation through stratum corneum. Herein, four cocrystals of 5FU with... The content of this RSS Feed (c) The Royal Society of Chemistry
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Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC04569D, CommunicationXinhu Lv, Xueyuan Wang, Yan Zhou, Hai Xu, Wen-Ming Wan A new type of organic proton donor for strong-acid/base-free hydrogen evolution reaction is reported, by taking advantage of the electron deficience of boron center of borinic acid and the strong... The content of this RSS Feed (c) The Royal Society of Chemistry
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NSF Director France Córdova reflects on the anniversary of the Moon Landing and how the power to captivate the world with science inspires us to pursue other once deemed impossible moonshots¬ólike detecting gravitational waves at NSF'S LIGO facility or imaging a black hole like the NSF funded ...This is an NSF Multimedia Gallery item.
Source: NSF Multimedia Gallery - Category: Science Source Type: video
OBJECTIVE: To describe and compare caffeinated energy drink adverse event (AE) report/exposure call data from the US Food and Drug Administration Center for Food Safety and Applied Nutrition's Adverse Event Reporting System (CAERS) and the American Associa...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
This article considers the public history of slavery at plantation museums in the US South and at country houses in Britain. Drawing on original research, the authors critique recent and current efforts to bring connections between these "Big Houses" and t...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Commentary Source Type: news
Conclusion Starter cultures are an important tool that contributes to ensure the safety of fermented meat products. Indeed, the microorganisms that constitute starter cultures may inhibit or reduce the growth of spoilage and/or pathogenic populations through mechanisms, such as production of certain metabolites or competitive exclusion. Thus, the use of starter cultures may reduce the need for chemical additives, such as nitrites and nitrates. Furthermore, the lower residual levels of nitrates and nitrites detected in fermented meat products inoculated with starter cultures are due to the ability of starters to metabolize...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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