Identifying Gut Microbiota Associated With Colorectal Cancer Using a Zero-Inflated Lognormal Model
In this study, we identified the differentially abundant gut microbes between CRC and healthy samples using the Ratio Approach for Identifying Differential Abundance (RAIDA) algorithm (Sohn et al., 2015). The algorithm fitted the distribution of observed data with a modified zero-inflated lognormal (ZIL) model and estimated the statistical significance of abundance difference by the T-test. Furthermore, we used the GRAMMy algorithm (Xia et al., 2011) to estimate and analyze the relative abundance of gut microbes and diversity of the microbial communities. Finally, we constructed and analyzed a microbial association network based on all healthy, small adenoma, large adenoma, and CRC samples. Materials and Methods Two Metagenomics Datasets Our first gut metagenomics dataset was downloaded from the European Nucleotide Archive (ENA) database (accession number ERP005534) (Table 1). The dataset (Zeller et al., 2014) consists of 156 samples from France (61 healthy, 27 small adenoma, 15 large adenoma, and 53 CRC samples). Samples with an adenoma diameter smaller than 10 mm were classified as small adenoma while those with larger than 10 mm ones were classified as large adenoma. TABLE 1 Table 1. Number of experimental samples. Our second gut metagenomics dataset was also downloaded from the ENA database (accession number ERP008729) (Zeller et al., 2014). The dataset included 156 samples from Austria, including 63 healthy samples, 47 adenoma patient samples, and 46 CR...
Publication date: December 2020Source: Social Science &Medicine, Volume 266Author(s): Trang Thu Do, Andrea Whittaker
Publication date: 1 January 2021Source: Personality and Individual Differences, Volume 168Author(s): Feizhong Zheng, Wenting Wu, Lijing Wang, Arlette J. Ngoubene-Atioky, Li Chen
Resumo O fil ósofo francês Michel Foucault discute a psicanálise através de seu método arqueológico da constituição dos saberes na modernidade. A análise foucaultiana revela uma reestruturação crítica dos saberes, que parte do estudo das estruturas sociais, atribuindo a estas um caráter arbitrário e cerceador. Neste ponto, o autor se detém no modo como a psicanálise freudiana pensa a dinâmica das relações sociais ao construir uma linguagem. Contudo, Foucault encontra nesta proposta um dom&iacut...
You could consider this a follow-up to one of last week’s posts: Are You Most Loyal to Purpose or People? I want to share another way of framing the mindset of being loyal to purpose ahead of people, especially for those who’d prefer to shift into greater loyalty to purpose. Putting purpose first isn’t dehumanizing if you frame it a certain way – if your purpose actually involves serving people. If, however, your purpose is mainly self-centered, like if it’s based on individual achievements that will be of little or no benefit to others, then I think you’re more likely to run in...
Publication date: November 2020Source: Human Pathology: Case Reports, Volume 22Author(s): Susha Varghese, Timothy Helliwell, Chandrasekar Coonoor
Publication date: November 2020Source: Human Pathology: Case Reports, Volume 22Author(s): Shohei Matsuo, Yoshitane Tsukamoto, Eiichiro Mabuchi, Shunichi Negoro, Seiichi Hirota
Publication date: Available online 22 September 2020Source: Pathology - Research and PracticeAuthor(s): Yasamin Pahlavan, Mina Mohammadi Nasr, Elaheh Dalir Abdolahinia, Zahra Pirdel, Saiedeh Razi Soofiyani, Samaneh Siahpoush, Kazem Nejati
Publication date: Available online 21 September 2020Source: Pathology - Research and PracticeAuthor(s): He Zhang, Yi Wang, Yanfeng Wang, Daoyuan Wu, Enguang Lin, Qingxin Xia
Publication date: Available online 21 September 2020Source: Pathology - Research and PracticeAuthor(s): Yuichi Koyama, Teppei Morikawa, Yu Miyama, Jimpei Miyakawa, Taketo Kawai, Haruki Kume, Motoji Sawabe, Tetsuo Ushiku
Publication date: September–October 2020Source: Revista Española de Cirugía Ortopédica y Traumatología (English Edition), Volume 64, Issue 5Author(s): D. Godoy-Monzon, A. Garcia-Mansilla, M. Buljubasich, A. Cid-Casteulani, R. Valentini
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