Identifying Gut Microbiota Associated With Colorectal Cancer Using a Zero-Inflated Lognormal Model

In this study, we identified the differentially abundant gut microbes between CRC and healthy samples using the Ratio Approach for Identifying Differential Abundance (RAIDA) algorithm (Sohn et al., 2015). The algorithm fitted the distribution of observed data with a modified zero-inflated lognormal (ZIL) model and estimated the statistical significance of abundance difference by the T-test. Furthermore, we used the GRAMMy algorithm (Xia et al., 2011) to estimate and analyze the relative abundance of gut microbes and diversity of the microbial communities. Finally, we constructed and analyzed a microbial association network based on all healthy, small adenoma, large adenoma, and CRC samples. Materials and Methods Two Metagenomics Datasets Our first gut metagenomics dataset was downloaded from the European Nucleotide Archive (ENA) database (accession number ERP005534) (Table 1). The dataset (Zeller et al., 2014) consists of 156 samples from France (61 healthy, 27 small adenoma, 15 large adenoma, and 53 CRC samples). Samples with an adenoma diameter smaller than 10 mm were classified as small adenoma while those with larger than 10 mm ones were classified as large adenoma. TABLE 1 Table 1. Number of experimental samples. Our second gut metagenomics dataset was also downloaded from the ENA database (accession number ERP008729) (Zeller et al., 2014). The dataset included 156 samples from Austria, including 63 healthy samples, 47 adenoma patient samples, and 46 CR...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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Authors: Soumah A, Avettand-Fenoel V, Veber F, Moshous D, Mahlaoui N, Blanche S, Frange P Abstract OBJECTIVES: To assess the outcome of HIV-infected individuals attending one of the largest French pediatric HIV centers in 2016-2017 and to compare the rates of antiretroviral coverage and virological suppression with the UNAIDS targets. PATIENTS AND METHODS: The clinical and immuno-virological status of 163 HIV-1-infected children and adolescents attending Necker Hospital in Paris, France, were investigated. Virological suppression was defined as an HIV-1 viral load
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Publication date: Available online 14 November 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Mariceli Comellas, Yamile Marrero, Florence George, Lisa MatthewsAbstractAimTo assess the age and its association with glycemic control (GC) among adults with type 2-diabetes in the United States.Materials and MaterialsData were collected from the National Nutrition Examination Survey (NHANES) 2013 -2014 (n=697), cross-sectional national survey adults with Type2 diabetes. Characteristics included retinopathy diagnosis, blood pressure, albumin-creatinine ratio, hemoglobin A1c (HbA1c), BMI, ch...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 15 November 2019Source: Pharmacological ResearchAuthor(s): Hao Jia, Haixia Peng, Zhaoyuan HouAbstractThe LIM protein Ajuba contains an unstructured proline/glycine-rich preLIM region in the N terminus and conserved tandem LIM motifs in the C terminus. Additionally, Ajuba contains both nuclear export sequences (NES) and nuclear localization sequences (NLS), which enable Ajuba shuttle between the cytoplasm and the nucleus. Thus, Ajuba can act as a versatile scaffold participating in assembly of variety of protein complexes to execute multiple cellular functions including cell adhesion, moti...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 14 November 2019Source: Pharmacological ResearchAuthor(s): Mingxue Li, Dun Wang, Jianhua He, Lixia Chen, Hua LiAbstractB-cell lymphoma-extra large (Bcl-XL) is one of the anti-apoptotic proteins of the Bcl-2 family that is localized in the mitochondria. Bcl-XL is one of the key regulators of apoptosis that can also regulate other important cellular functions. Bcl-XL is overexpressed in many cancers, and its inhibitors have shown good therapeutic effects. Bcl-XL interacts with Beclin 1, a key factor regulating autophagy.Bcl-XL is essential for the survival of neurons and plays protective ro...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 14 November 2019Source: Pharmacological ResearchAuthor(s): Lijuan Wu, Fei Li, Changying Zhao, Yao Ming, Chunmei Zheng, Yonglin Li, Shihang Lei, Chen ChenAbstractThe incidence of ischemic cardiomyopathy (ICM) is increasing yearly, which seriously endangers human health. There is rarely any remarkable progress in the treatment of ICM from the available drugs. Recent research shows that natural herbal medicine may have beneficial effects in the prevention and treatment of cardiovascular diseases. The effective extracts of the herbs may improve myocardial ischemia through various actions, suc...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
In conclusion, a dynamic urinary metabolomics approach was applied to identify potential biomarkers of the development of BSS and to clarify the therapeutic mechanism of DSD in BSS. The results could provide a theoretical basis for further research on the therapeutic mechanism of DSD.Graphical abstract
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
ConclusionsWe found that EFVF is safe with regard to acute toxicity in rats as well as genotoxicity such as mutagenesis or clastogenesis under the present experimental conditions. These results might support the safety of EFVF as a potential therapeutic material for the traditional use or pharmaceutical development.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Leow K, Lynch MF, Lee J PMID: 31718228 [PubMed - as supplied by publisher]
Source: International Journal of Aging and Human Development - Category: Geriatrics Tags: Int J Aging Hum Dev Source Type: research
Ying Wang, Lin Fan, Y. Cheng, K. Huang and Hongwei Fan*
Source: Indian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research
A. Praveena*, S. Arthi and B. Sudarmathi
Source: Indian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research
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