Role of Fibroblast Populations in Periodontal Wound Healing and Tissue Remodeling

Conclusions Fibroblasts play a critical role during periodontal wound healing. These cell populations are needed for the regeneration of a stable fibrillar connection between the tooth root, the gingiva, and the periodontal ligament. Importantly, regeneration of connective tissues involves different cellular activities driven by fibroblasts populations. These include the secretion of matrix molecules and the organization of these matrix components into functionally active fibers that finally restore the periodontium. Future studies should explore the cellular and molecular regulation of these cell populations and gain a more detailed understanding of the above-described mechanisms. This is critically important for the development of novel therapeutic approaches designed to regenerate periodontal tissues. Author Contributions All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication. Funding The authors acknowledge the Chilean Fund for Science and Technology (FONDECYT) grants number 1170555 (PS), 1181007 (CM), 1181168 (JM) and the Canadian Institutes of Health Research Operating Grant 416228 (CAM). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References Arora, P. D., Narani, N., and McCulloch, C. A. (1999). The compliance of collag...
Source: Frontiers in Physiology - Category: Physiology Source Type: research