An Adaptive Multivariate Two-Sample Test With Application to Microbiome Differential Abundance Analysis

This study involves only secondary analyses, where all the utilized data sets are published in a previous study. Author Contributions KB and NZ analyzed the data, drafted the paper, prepared figures and tables, AS and LX conducted the testing subset simulations, SH and FM provided and helped analyze the oral microbiome data. RW contributed substantial expertise to improve the paper and revised the paper. XZ conceived and designed the experiments, analyzed the data, wrote the paper, and software. All authors read and approved the final manuscript. Funding This work was supported by Quadrant Biosciences Inc. (Research agreement with SH), the National Institutes of Health grants R41 MH111347 (FM), P50 DA039838 (LX) and National Science Foundation grant DMS-1811552 (LX). Conflict of Interest Statement The authors declare that this study received funding from a National Institutes of Mental Health STTR award (R41 MH111347) to Quadrant Biosciences, Inc. Quadrant Biosciences was involved with study design, and data collection for the RNA sequencing results employed in this study's secondary data analysis (autism microbiome data). SH and FM serve on the scientific and medical advisory boards of Quadrant Biosciences Inc., and SH is a paid consultant for Quadrant Biosciences Inc. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments The...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research