Receptor-Interacting Serine/Threonine Kinase 3 (RIP3) –Mixed Lineage Kinase Like Protein (MLKL)–Mediated Necroptosis Contributes to Ischemia-Reperfusion Injury of Steatotic Livers

Increased hepatic ischemia-reperfusion (IR) injury in steatotic livers is a major reason for rejecting the use of fatty livers for liver transplantation. Necroptosis is implicated in the pathogenesis of fatty liver diseases. Necroptosis is regulated by three key proteins: receptor-interacting serine/threonine kinase 1 (RIP1; official name RIPK1), RIP3, and mixed lineage kinase like protein (MLKL). Here, we found that western diet (WD) induced marked steatosis in mouse livers, which was associated with the inhibition of hepatic proteasome activities and increased levels of key necroptosis proteins.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research