Reduced Interhemispheric White Matter Asymmetries in Medial Temporal Lobe Epilepsy With Hippocampal Sclerosis

Conclusion The current study found that the interhemispheric asymmetries in FA were significantly lower in both the LMTLE-HS group and the RMTLE-HS group than in the HC group. The ROI-based quantitative analysis provided further evidence for the previous result that RMTLE-HS/LMTLE-HS influences the ipsilateral hemisphere more severely and that impairment in LMTLE-HS may be more diffuse and bilateral than that in RMTLE-HS. The differences in AI among RMTLE-HS, LMTLE-HS, and HC involved the limbic system and the SLF, which may have some pragmatic implications as to the diagnosis of MTLE and the differentiation of LMTLE-HS from RMTLE-HS. Ethics Statement This study was carried out in accordance with the recommendations of the Ethical Committee of Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Ethical Committee of Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology. Author Contributions XZ, ZZ, and WZ were responsible for the study design, data interpretation and writing the manuscript. YX, XZ, XP, and ZZ contributed to MRI data acquisition, TBSS processing, ROI-based quantitative analyzing and AI analyzing. XC, KX, JL, and YH assisted in recruiting subjects, acquiring MRI data and collecting clinical data. WZ revised the f...
Source: Frontiers in Neurology - Category: Neurology Source Type: research