Controlled in vivo Bone Formation and Vascularization Using Ultrasound-Triggered Release of Recombinant Vascular Endothelial Growth Factor From Poly(D,L-lactic-co-glycolicacid) Microbubbles

In conclusion, we demonstrated the use of VEGF-loaded MB for enhancing calvarial defects by UTMD burst release. Results showed that VEGF-loaded MB combined with UTMD promoted osteogenesis in vitro and enhanced bone repair in vivo compared with those groups without UTMD treatment. Ethics Statement This study was carried out in accordance with the recommendations of Guide for the Care and Use of Laboratory Animals, the Southern Medical University Institutional Animal Care and Use Committee. The protocol was approved by the Southern Medical University Institutional Animal Care and Use Committee. Author Contributions YG, YC, and BY designed the experiment. YG, JY, WZ, and SL performed the experiment. YG investigated the study and wrote the manuscript. BY acquired funding, contributed to resources, and supervised the study. Funding This work was supported by the National Natural Science Foundation of China (grant number: 81871355, 81371931, and 81301240). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer CC declared a past co-authorship with one of the authors with the author BY to the handling editor. References Bekeredjian, R., Katus, H., and Kuecherer, H. (2006). Therapeutic use of ultrasound targeted microbubble destruction: a review of non-cardiac applications. Ultraschall. Me...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research