Loganin Exerts Sedative and Hypnotic Effects via Modulation of the Serotonergic System and GABAergic Neurons

In conclusion, these results indicated that loganin produced beneficial sedative and hypnotic activity, which might be mainly mediated by modification of the serotonergic system and GABAergic neurons. Introduction Insomnia is referred to as continuous difficulty in initiating or maintaining sleep, which can induce extreme medical and psychiatric disorders (Cao et al., 2016). It was reported that 27 percent of people in the world suffering from insomnia (Doghramji, 2006), and approximately 3–10 percent of people would frequently depend on hypnotics to overcome insomnia by 2050 (Chu et al., 2007). Clinically, benzodiazepines are the most extensively used drug for insomnia. Nevertheless, serious side effects are always accompanied with their treatment, including drug dependence, drug tolerance, rebound insomnia, and amnesia (Griffiths et al., 1986; Bocca et al., 1999). Zolpidem and zopiclone, a new type of hypnotic, also show some undesirable side effects. Therefore, novel drug for insomnia with better effect and less side effect deserves more effort, and novel herbal ingredients in traditional Chinese medicine might be a better choice for drug discovery (Griffiths et al., 1986). Corni fructus, the fruit of Cornus officinalis Sieb. et Zucc. (Cornaceae), has long been used to nourish the liver and kidney and treat diabetes and other diseases in China, Korea, and Japan (Lee et al., 2009). Loganin (Figure 1), a major iridoid glycoside isolated from Corni fructus, has...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Source: Biotechnology Reports - Category: Biotechnology Source Type: research
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Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
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Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
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Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research
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Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research
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Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research
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Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research
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