Loganin Exerts Sedative and Hypnotic Effects via Modulation of the Serotonergic System and GABAergic Neurons

Conclusion In conclusion, this is the first study to confirm the sedative and hypnotic effects of loganin. Moreover, 5-HT, DA, and GAD activation might be involved in the mechanism of sleep-promoting effect and sleep architecture regulation of loganin. Other mechanisms involved in the sedative and hypnotic effects of loganin deserve more attention and further investigation. Taken together, these findings suggest that loganin might be a potential candidate drug for insomnia. Ethics Statement This study was carried out in accordance with the recommendations of “National Institutes of Health Guide for the Care and Use of Laboratory Animals of China.” The protocol was approved by the “Animal Care Committee of China-Japan Friendship Hospital.” Author Contributions J-KX and W-KZ designed the research and polished the manuscript. RS, YH, and H-YQ performed the experiments. T-LL provided the EGG and EMG instruments and experimental guidance. RS, YH, and YY drafted the manuscript. JH, W-WL, and C-YX revised the manuscript. Funding This work was supported by G20 Engineering Innovation Research Project of Beijing Municipal Science and Technology Commission (Nos. Z171100001717009 and Z181100002218029), Chinese Academy of Medical Sciences Basic Research Business Fund Youth Medical Talent Award Project (No. 2018RC350019), and Distinguished Young Talents Project of Beijing University of Chinese Medicine (No. 2018-JYB-XJQ007). Conflict of Interest Statemen...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research