STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia

ConclusionsThese data establish the critical role of a newly discovered BCR independent Ca2+ entry in CLL evolution, provide new insights into CLL pathophysiology, and support innovative therapeutic perspectives such as targeting STIM1 located at the plasma membrane.

Source: Journal for Immunotherapy of Cancer - April 22, 2019 Category: Cancer & Oncology Source Type: research